Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Research on a fast self-healing control method for tie-line faults in regional distribution networks based on source-load-storage interaction. [PDF]
Zhou C, Gui S, Gao G, Liu C, Ma Y.
europepmc +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
From Sarracenia to scientific application: harnessing the potential of porous bionic cones for accelerated directional movement of droplets. [PDF]
Gao D +8 more
europepmc +1 more source
Small RNA pathways in mammalian oocytes
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Adaptation of Non-Invasive Cancer Cells to 3D Collagen I Microenvironment Induces Transcriptional Reprogramming Accompanied by a More Complex RNA Landscape. [PDF]
Wießner-Kroh T +6 more
europepmc +1 more source
ALKBH10B mediated epitranscriptomic regulation enhances drought tolerance of Arabidopsis thaliana via hormonal cross-talk and sustained photosynthesis. [PDF]
Shoaib Y +8 more
europepmc +1 more source
Clay field therapy for complex PTSD: a single-case study with HRV measurement. [PDF]
Démurger M, Pomini V.
europepmc +1 more source
Tripartite evolutionary game analysis of medical data governance: interactions among government, medical institutions, and third-party assessment agencies. [PDF]
Liu X, Gong J, Liu J.
europepmc +1 more source
From immature to mature epithelium: unveiling structural dynamics and transcriptional programs in rainbow trout intestinal barrier. [PDF]
Talamilla-Espinoza A +9 more
europepmc +1 more source

