Results 91 to 100 of about 10,265,072 (333)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
An Innovative Hybrid Approach Producing Trial Solutions for Global Optimization
Applied SciencesGlobal optimization is critical in engineering, computer science, and various industrial applications as it aims to find optimal solutions for complex problems. The development of efficient algorithms has emerged from the need for optimization, with each
Vasileios Charilogis +3 more
doaj +1 more source
, 2018 In this paper, we propose a successive convex approximation framework for sparse optimization where the nonsmooth regularization function in the objective function is nonconvex and it can be written as the difference of two convex functions. The proposed
Chatzinotas, Symeon +3 more
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Anew Conjugate Gradient Algorithm Based on The (Dai-Liao) Conjugate Gradient Method
Tikrit Journal of Pure Science, 2020 In this paper we can derive a new search direction of conjugating gradient method associated with (Dai-Liao method ) the new algorithm becomes converged by assuming some hypothesis.
SHAHER QAHTAN HUSSEIN +2 more
doaj +1 more source
Optimization via Chebyshev Polynomials
, 2017 This paper presents for the first time a robust exact line-search method based on a full pseudospectral (PS) numerical scheme employing orthogonal polynomials.
Elgindy, Kareem T.
core +1 more source
tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genes
Nucleic Acids Res., 2016 High-throughput genome sequencing continues to grow the need for rapid, accurate genome annotation and tRNA genes constitute the largest family of essential, ever-present non-coding RNA genes. Newly developed tRNAscan-SE 2.0 has advanced the state-of-the-
T. Lowe, Patricia P. Chan
semanticscholar +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Hybrid Modified Accelerated Gradient Method for Optimization Processes
MathematicsThis research reveals a hybrid variant of the modified accelerated gradient method. We prove that derived iteration is linearly convergent on the set of uniformly convex functions.
Milena J. Petrović +2 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source