Results 61 to 70 of about 10,265,072 (333)
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
X-ray Line Emitting Objects in XMM-Newton Observations: the Tip of the Iceberg
, 2004 We present preliminary results from a novel search for X-ray Line Emitting Objects (XLEOs) in XMM-Newton images. Three sources have been detected in a test-run analysis of 13 XMM-Newton observations.
A. Caccianiga +6 more
core +2 more sources
Dark matter line emission constraints from NuSTAR observations of the Bullet Cluster [PDF]
, 2015 Line emission from dark matter is well motivated for some candidates e.g. sterile neutrinos. We present the first search for dark matter line emission in the 3-80keV range in a pointed observation of the Bullet Cluster with NuSTAR.
Boggs, S. E. +12 more
core +4 more sources
Gradient-only line searches: An Alternative to Probabilistic Line Searches
, 2019 Step sizes in neural network training are largely determined using predetermined rules such as fixed learning rates and learning rate schedules. These require user input or expensive global optimization strategies to determine their functional form and associated hyperparameters. Line searches are capable of adaptively resolving learning rate schedules.
Kafka, Dominic, Wilke, Daniel
openaire +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Mathematics, 2018 In this paper, three-step Taylor expansion, which is equivalent to third-order Taylor expansion, is used as a mathematical base of the new descent method. At each iteration of this method, three steps are performed.
Mina Torabi, Mohammad-Mehdi Hosseini
doaj +1 more source
An Efficient Line Search Algorithm for Large Scale Optimization [PDF]
Al-Rafidain Journal of Computer Sciences and Mathematics, 2010 In this work we present a new algorithm of gradient descent type, in which the stepsize is computed by means of simple approximation of the Hessian Matrix to solve nonlinear unconstrained optimization function.
Abbas Al-Bayati, Ivan Latif
doaj +1 more source
A symmetric rank-one Quasi-Newton line-search method using negative curvature directions [PDF]
, 2010 We propose a quasi-Newton line-search method that uses negative curvature directions for solving unconstrained optimization problems. In this method, the symmetric rank-one (SR1) rule is used to update the Hessian approximation.
Birbil, S. Ilker +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source