Results 71 to 80 of about 10,265,072 (333)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Search of sub-parsec massive binary black holes through line diagnosis II [PDF]
, 2011 Massive black hole binaries at sub-parsec separations may display in their spectra anomalously small flux ratios between the MgII and CIV broad emission lines, i.e. F_MgII/F_CIV
Artymovicz +34 more
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
MathematicsUnconstrained optimization problems have a long history in computational mathematics and have been identified as being among the crucial problems in the fields of applied sciences, engineering, and management sciences. In this paper, a new variant of the
Aliyu Muhammed Awwal +3 more
doaj +1 more source
A Combined Cubic and Novel Line Search CG-Algorithm [PDF]
Al-Rafidain Journal of Computer Sciences and Mathematics, 2012 In this paper a new line search technique is investigated. It uses (cubic and novel) line searches in the standard CG-algorithm for unconstrained optimization.
Abbas Al-Bayati, Hamsa Chilmerane
doaj +1 more source
Primal-dual accelerated gradient methods with small-dimensional relaxation oracle
, 2019 In this paper, a new variant of accelerated gradient descent is proposed. The pro-posed method does not require any information about the objective function, usesexact line search for the practical accelerations of convergence, converges accordingto the ...
Dvurechensky, Pavel +3 more
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Iterative Beam Search for Simple Assembly Line Balancing with a Fixed Number of Work Stations [PDF]
, 2010 The simple assembly line balancing problem (SALBP) concerns the assignment of tasks with pre-defined processing times to work stations that are arranged in a line. Hereby, precedence constraints between the tasks must be respected.
Blum, Christian
core +3 more sources
Applied Sciences, 2019 This paper presents a novel algorithm for structural reliability analysis based on the finite step length and Armijo line search to remove the drawbacks of the Hasofer–Lind and Rakwitz–Fiessler (HL-RF) algorithm that may be subjected to non-convergence ...
Huang
semanticscholar +1 more source
A Line-Search Algorithm Inspired by the Adaptive Cubic Regularization Framework and Complexity Analysis [PDF]
Journal of Optimization Theory and Applications, 2018 Adaptive regularized framework using cubics has emerged as an alternative to line-search and trust-region algorithms for smooth nonconvex optimization, with an optimal complexity among second-order methods.
E. Bergou, Y. Diouane, S. Gratton
semanticscholar +1 more source