Results 71 to 80 of about 820,651 (313)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
AxiomsAn upgrade to the quasi-Newton (QN) family of methods for solving unconstrained optimization problems is proposed. This research focuses on a detailed investigation of the Barzilai and Borwein (BB) gradient methods.
Predrag S. Stanimirović +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Probabilistic Line Searches for Stochastic Optimization
, 2015 12 pages, including ...
Mahsereci, M., Hennig, P.
openaire +6 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Euphemisms and dysphemism: in search of a boundary line
Círculo de Lingüística Aplicada a la Comunicación, 2011 Straightforward remarks may sometimes be regarded as either an offence or an indelicacy. That is the reason why, to avoid the danger of being perceived vulgar or illmannered, language users prefer to employ a range of so-called concealing mechanisms ...
Bożena Duda
doaj +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Joint trade-off optimization algorithm based on cooperative spectrum sensing throughput
Tongxin xuebao, 2011 The achievable data throughput of the cognitive network was modeled to optimize the overhead and performance of the cooperative system thoroughly.Considering the soft data combination decision,the joint trade-off optimization of the local sampling number
Guo-qing JI, Gang WANG, Hong-bo ZHU
doaj
Adaptive Backtracking Line Search
Backtracking line search is foundational in numerical optimization. The basic idea is to adjust the step-size of an algorithm by a constant factor until some chosen criterion (e.g. Armijo, Descent Lemma) is satisfied. We propose a novel way to adjust step-sizes, replacing the constant factor used in regular backtracking with one that takes into account
Cavalcanti, Joao V. +2 more
openaire +2 more sources