Results 81 to 90 of about 10,265,072 (333)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
MathematicsThis paper proposes a new proximal iteratively reweighted nuclear norm method for a class of nonconvex and nonsmooth optimization problems. The primary contribution of this work is the incorporation of line search technique based on dimensionality ...
Zhili Ge, Siyu Zhang, Xin Zhang, Yan Cui
doaj +1 more source
The Search for Million Degree Gas Through The NVII Hyperfine Line
, 2007 Gas in the million degree range occurs in a variety of astronomical environments, and it may be the main component of the elusive missing baryons at low redshift.
Garwood R. +4 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Relay UAV motion control method for airborne multi-agent systems
工程科学学报Compared to single-agent systems, multi-agent systems exhibit advantages such as high efficiency and strong survivability in task execution. However, an increase in distance increases the difficulty for agents to communicate with each other and also ...
Cancan TAO, Ronghao WANG
doaj +1 more source
Group Search on the Line [PDF]
, 2015 In this paper we consider the group search problem, or evacu- ation problem, in which k mobile entities (\({\cal M}{\cal E}\)s) located on the line perform search for a specific destination. The \({\cal M}{\cal E}\)s are initially placed at the same origin on the line L and the target is located at an unknown distance d, either to the left or to the ...
Chrobak, Marek +3 more
openaire +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
AtmosphereThis paper introduces an efficient approach for implementing the Four-Dimensional Variational Ensemble Kalman Filter (4D-EnKF) for non-linear data assimilation, leveraging a modified Cholesky decomposition (4D-EnKF-MC).
Elías D. Nino-Ruiz +1 more
doaj +1 more source