Results 51 to 60 of about 6,005,333 (282)

Predicting the Biological Effects of Human Salivary Gland Tumour Cells for Scanned ⁴He-, ¹²C-, ¹⁶O-, and ²⁰Ne-Ion Beams Using an SOI Microdosimeter

Applied Sciences, 2022
Experimental microdosimetry along with the microdosimetric kinetic (MK) model can be utilized to predict the biological effects of ions. To predict the relative biological effectiveness (RBE) of ions and the survival fraction (SF) of human salivary gland
Sung Hyun Lee, Kota Mizushima, Shunsuke Yonai, Shinnosuke Matsumoto, Hideyuki Mizuno, Taku Nakaji, Ryosuke Kohno, Yoshiyuki Iwata, Toshiyuki Shirai, Vladimir Pan, Angela Kok, Marco Povoli, Linh T. Tran, Anatoly B. Rosenfeld, Masao Suzuki, Taku Inaniwa   +15 more
doaj   +1 more source

On the use of Lineal Energy Measurements to Estimate Linear Energy Transfer Spectra [PDF]

, 2007
This paper examines the error resulting from using a lineal energy spectrum to represent a linear energy transfer spectrum for applications in the space radiation environment. Lineal energy and linear energy transfer spectra are compared in three diverse
Howell, Leonard W., Jr., Adam, James H., Jr., Adams, David A.   +2 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A model for relative biological effectiveness of therapeutic proton beams based on a global fit of cell survival data

Scientific Reports, 2017
We introduce an approach for global fitting of the recently published high-throughput and high accuracy clonogenic cell-survival data for therapeutic scanned proton beams.
Ramin Abolfath, Christopher R. Peeler, Mark Newpower, Lawrence Bronk, David Grosshans, Radhe Mohan   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Characterizing Radiation Effectiveness in Ion-Beam Therapy Part II: Microdosimetric Detectors

Frontiers in Physics, 2020
The specific advantages of ion beams for application in tumor therapy are attributed to their different macroscopic and microscopic energy deposition pattern as compared to conventional photon radiation.
Paolo Colautti, Giulio Magrin, Hugo Palmans, Hugo Palmans, Miguel A. Cortés-Giraldo, Valeria Conte   +5 more
doaj   +1 more source

Average value of the dose-mean lineal energy y_D for FF and FFF beams.

, 2018
Average value of the dose-mean lineal energy yD for FF and FFF beams.
Daisuke Kawahara (6000239), Kaoru Ono (1969618), Yukio Akagi (6000242), Yutaka Hirokawa (6000245), Hisashi Nakano (6000236)   +4 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Aplicaciones de los métodos de optimización en el diseño de Sistemas Híbridos Eólico – Fotovoltáicos para las condiciones tropicales cubanas. // Optimization methods application of hybrid eolic- photovoltaic systems in tropical conditions.

Ingeniería Mecánica, 2002
En este trabajo se plantea la aplicación y optimización de métodos en el diseño de sistemas híbridos eólico-fotovoltáicos loscuales se fundamentan en una programación lineal, para esto es analizada una instalación energética y la demandaenergética ...
M. Menéndez González, A. Sarmiento Sera   +1 more
doaj