Results 101 to 110 of about 21,191,435 (272)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
International Journal of Electrical Power & Energy SystemsDoubly-fed induction generator (DFIG) is susceptible to unbalanced grid voltage and mismatched motor parameters during grid-connected operation. The conventional model predictive control (MPC) has low complexity and fast dynamic response, which is widely
Hui Jin, Zhenxiong Zhou, Pingping Qu
doaj +1 more source
Performance recovery of nonlinear model helicopter using extended high gain observer
, 2009 Nonlinear control methods are difficult to work on an unmanned helicopter system for its inherently unstable, high-order, and cross-coupled dynamic characters.
Zheng Wang +5 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Frequency Performance of the Extended State Observer for General Systems
, 2013 : The observing capability of the Active Disturbance Rejection Control (ADRC) for the general systems is discussed in this study. The frequency performance of the Linear Extended State Observer (LESO) is analyzed.
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Sliding mode control of excavator electro-hydraulic system based on linear extended state observer
Journal of Measurement Science and InstrumentationThe actual working environment of unmanned excavation robot is harsh. In order to improve the trajectory tracking accuracy of bucket under load disturbance, a nonlinear mathematical model of electro-hydraulic system of digging robot was established, and ...
ZHANG Sen, ZHANG Ping, ZHAO Zhe
doaj