Results 61 to 70 of about 560,929 (291)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Remarks on interpolation in certain linear spaces (III)

Journal of Numerical Analysis and Approximation Theory, 2006
In this paper we study a way of extending the model of interpolating the real functions, with simple nodes, to the case of the functions defined between linear spaces, especially between linear normed spaces.
Adrian Diaconu
doaj   +2 more sources

Spatial analysis of precipitation in a high-mountain region: exploring methods with multi-scale topographic predictors and circulation types [PDF]

Hydrology and Earth System Sciences, 2014
Statistical models of the relationship between precipitation and topography are key elements for the spatial interpolation of rain-gauge measurements in high-mountain regions.
D. Masson, C. Frei
doaj   +1 more source

Counterexample-Guided Polynomial Loop Invariant Generation by Lagrange Interpolation

, 2015
We apply multivariate Lagrange interpolation to synthesize polynomial quantitative loop invariants for probabilistic programs. We reduce the computation of an quantitative loop invariant to solving constraints over program variables and unknown ...
A Chakarov, A Dolzmann, A Dolzmann, A Gupta, A Gupta, A McIver, C Boor De, CAR Hoare, D Kozen, EW Dijkstra, F Gretz, F Gretz, J Hartog Den, J-P Katoen, JW Eaton, L Moura de, M Uslar, MA Colón, MO Rabin, P Cousot, PJ Olver, RW Floyd, S Sankaranarayanan, T Sauer   +23 more
core   +1 more source

Digital linear interpolator

Electronics Letters, 1972
A substitution is made in the linear-interpolation function A(1−S)+B.S. This effectively halves the number of partial products in the binary expansion. The corresponding digital logic is an adaptation of a single multiplier.
openaire   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Quantifying steric hindrance and topological obstruction to protein structure superposition

Algorithms for Molecular Biology, 2021
Background In computational structural biology, structure comparison is fundamental for our understanding of proteins. Structure comparison is, e.g., algorithmically the starting point for computational studies of structural evolution and it guides our ...
Peter Røgen
doaj   +1 more source