Results 71 to 80 of about 3,822,020 (321)

On non-negative estimation of variance components in mixed linear models

Journal of Advanced Research, 2016
Alternative estimators have been derived for estimating the variance components according to Iterative Almost Unbiased Estimation (IAUE). As a result two modified IAUEs are introduced.
Heba A. El Leithy, Zakaria A. Abdel Wahed, Mohamed S. Abdallah   +2 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Best practice guidance for linear mixed-effects models in psychological science

Journal of Memory and Language, 2019
The use of Linear Mixed Effects Models (LMMs) is set to dominate statistical analyses in psychological science and may become the default approach to analyzing quantitative data. The rapid growth in adoption of LMMs has been matched by a proliferation of
L. Meteyard, Robert A. I. Davies
semanticscholar   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Efficient estimation of moments in linear mixed models

, 2012
In the linear random effects model, when distributional assumptions such as normality of the error variables cannot be justified, moments may serve as alternatives to describe relevant distributions in neighborhoods of their means.
Stute, Winfried, Wu, Ping, Zhu, Li-Xing
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Penalized Composite Likelihood Estimation for Spatial Generalized Linear Mixed Models [PDF]

Journal of Sciences, Islamic Republic of Iran
When discussing non-Gaussian spatially correlated variables, generalized linear mixed models have enough flexibility for modeling various data types. However, the maximum likelihood methods are plagued with substantial calculations for large data sets ...
Mohsen Mohammadzadeh, Leyla Salehi
doaj   +1 more source

Understanding correlates of child stunting in Ethiopia using generalized linear mixed models

BMC Public Health, 2019
BackgroundStunting is an indicator of the devastating result of malnutrition in early childhood. The effects of childhood stunting are irreparable physical and cognitive harm.
K. Takele, T. Zewotir, D. Ndanguza
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Comparison of genome-wide association methods in analyses of admixed populations with complex familial relationships. [PDF]

PLoS ONE, 2014
Population structure is known to cause false-positive detection in association studies. We compared the power, precision, and type-I error rates of various association models in analyses of a simulated dataset with structure at the population (admixture ...
Naveen K Kadri, Bernt Guldbrandtsen, Peter Sørensen, Goutam Sahana   +3 more
doaj   +1 more source