Results 71 to 80 of about 1,982,495 (283)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Revista Colombiana de Estadística, 2007 The mixed linear model is characterized using the classic linear model of Gauss-Markov. The multipliers of Lagrange are a tool to obtain the best lineal predictors (BLUP), we shown the results of Searle (1997), where some sums of the best linear unbiased
López Luis Alberto +2 more
doaj
Henderson's method approach to Kernel prediction in partially linear mixed models
Cumhuriyet Science Journal, 2020 In this article, we propose Kernel prediction in partially linear mixed models by using Henderson's method approach. We derive the Kernel estimator and the Kernel predictor via the mixed model equations (MMEs) of Henderson's that they give the best ...
Seçil Yalaz, Özge Kuran
doaj +1 more source
Fence methods for mixed model selection
, 2008 Many model search strategies involve trading off model fit with model complexity in a penalized goodness of fit measure. Asymptotic properties for these types of procedures in settings like linear regression and ARMA time series have been studied, but ...
Gu, Zhonghua +3 more
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Macro vs. Micro Methods in Non-Life Claims Reserving (an Econometric Perspective)
Risks, 2016 Traditionally, actuaries have used run-off triangles to estimate reserve (“macro” models, on aggregated data). However, it is possible to model payments related to individual claims. If those models provide similar estimations, we investigate uncertainty
Arthur Charpentier, Mathieu Pigeon
doaj +1 more source
Global and local distance-based generalized linear models [PDF]
, 2016 This paper introduces local distance-based generalized linear models. These models extend (weighted) distance-based linear models first to the generalized linear model framework. Then, a nonparametric version of these models is proposed by means of local
Boj, Eva +4 more
core +1 more source
A stochastic variational framework for fitting and diagnosing generalized linear mixed models
, 2014 In stochastic variational inference, the variational Bayes objective function is optimized using stochastic gradient approximation, where gradients computed on small random subsets of data are used to approximate the true gradient over the whole data set.
Nott, David J., Tan, Linda S. L.
core +1 more source