Results 71 to 80 of about 144,311 (304)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A Voronovskaya-type theorem for a positive linear operator

International Journal of Mathematics and Mathematical Sciences, 2006
We consider a sequence of positive linear operators which approximates continuous functions having exponential growth at infinity.
Alexandra Ciupa
doaj   +1 more source

Iterative Methods for Computing the Resolvent of Composed Operators in Hilbert Spaces

Mathematics, 2019
The resolvent is a fundamental concept in studying various operator splitting algorithms. In this paper, we investigate the problem of computing the resolvent of compositions of operators with bounded linear operators.
Yixuan Yang, Yuchao Tang, Chuanxi Zhu
doaj   +1 more source

On spectra of linearized operators for Keller–Segel models of chemotaxis [PDF]

, 2012
S. I. Dejak, Pavel M. Lushnikov, Yu. N. Ovchinnikov, Israel Michael Sigal   +3 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Symmetry operators and decoupled equations for linear fields on black hole spacetimes [PDF]

, 2016
Bernardo Araneda
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

On the conditional distribution of a multivariate Normal given a transformation – the linear case

Heliyon, 2019
We show that the orthogonal projection operator onto the range of the adjoint T⁎ of a linear operator T can be represented as UT, where U is an invertible linear operator. Given a Normal random vector Y and a linear operator T, we use this representation
Rajeshwari Majumdar, Suman Majumdar
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

TWO METHODS OF DESCRIBING 2-LOCAL DERIVATIONS AND AUTOMORPHISMS

Ural Mathematical Journal
In the present paper, we investigate 2-local linear operators on vector spaces. Sufficient conditions are obtained for the linearity of a 2-local linear operator on a finite-dimensional vector space. To do this, families of matrices of a certain type are
Farhodjon Arzikulov, Feruza Nabijonova, Furkat Urinboyev   +2 more
doaj   +1 more source