Results 81 to 90 of about 1,874,418 (326)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Observer for non‐linear systems with sampled measurements: Application to the friction factor estimation of a pipeline

IET Control Theory & Applications, 2021
This paper presents a new approach of the continuous‐discrete observer design for a class of uncertain state‐affine non‐linear systems. A high‐gain observer redesign is developed and analysed under insightful conditions.
O. Hernández‐González, F. Ramírez‐Rasgado, C. M. Astorga‐Zaragoza, M. E. Guerrero‐Sánchez, G. Valencia‐Palomo, A. E. Rodriguez‐Mata   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Investigation of the search method for the transformation functions of nonlinear systems to equivalent linear ones in geometric control theory [PDF]

Bulletin of the National Technical University "KhPI" A series of "Information and Modeling", 2018
One of the factors that prevent the expansion of the field of application of the geometric control theory (GСT) is the need to solve the system of partial differential equations with constraints in the form of differential inequalities for determining the transformation functions and connection between the variables of linear and nonlinear models.
Dmitrienko, V.D., Zakovorotny, A.Y., Mezentsev, N.V., Hlavchev, D.M.   +3 more
openaire   +2 more sources

Targeting engineering synchronization in chaotic systems

, 2015
A method of targeting engineering synchronization states in two identical and mismatch chaotic systems is explained in details. The method is proposed using linear feedback controller coupling for engineering synchronization such as mixed synchronization,
Bhowmick, Sourav K., Ghosh, Dibakar
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Optimal control of nonlinear systems with input constraints using linear time varying approximations

Nonlinear Analysis, 2016
We propose a new method to solve input constrained optimal control problems for autonomous nonlinear systems affine in control. We then extend the method to compute the bang-bang control solutions under the symmetric control constraints.
Mehmet Itik
doaj   +1 more source

On Convergence of the Inexact Rayleigh Quotient Iteration with the Lanczos Method Used for Solving Linear Systems

, 2015
For the Hermitian inexact Rayleigh quotient iteration (RQI), the author has established new local general convergence results, independent of iterative solvers for inner linear systems.
A. Stathopoulos, B. N. Parlett, C. C. Paige, C. C. Paige, F. A. Dul, F. Xue, F. Xue, G. H. Golub, G. W. Daniel, G. W. Stewart, H. A. Vorst van der, I. S. Duff, J. Berns-Müller, J. Berns-Müller, J. Eshof van den, M. A. Freitag, M. A. Freitag, M. A. Freitag, M. A. Freitag, M. E. Hochestenbach, M. E. Hochstenbach, P. Smit, V. Simoncini, Y. Notay, Y. Saad, Z. X. Jia, ZhongXiao Jia   +26 more
core   +1 more source