Results 101 to 110 of about 194,123 (316)

Discrete-time output feedback sliding-mode control design for uncertain systems using linear matrix inequalities [PDF]

, 2011
An output feedback-based sliding-mode control design methodology for discrete-time systems is considered in this article. In previous work, it has been shown that by identifying a minimal set of current and past outputs, an augmented system can be ...
Floquet, Thierry, Sarah K. Spurgeon, Spurgeon, Sarah,, Thierry Floquet, Spurgeon, Sarah K., Govindaswamy, Srinath, Spurgeon, Sarah, K., Srinath Govindaswamy   +7 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Formulation of the actual state principle for a physical system [PDF]

Нанотехнологии в строительстве
Introduction. The article briefly discusses the state of scientific research in the field of mathematical modeling of physical systems with distributed parameters. Mathematical modeling in elasticity theory. The initial boundary value problem of linear
Boris V. Gusev, Vasily V. Saurin
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Exact Null Controllability, Stabilizability, and Detectability of Linear Nonautonomous Control Systems: A Quasisemigroup Approach

Abstract and Applied Analysis, 2018
In the theory control systems, there are many various qualitative control problems that can be considered. In our previous work, we have analyzed the approximate controllability and observability of the nonautonomous Riesz-spectral systems including the ...
Sutrima Sutrima, Christiana Rini Indrati, Lina Aryati   +2 more
doaj   +1 more source

Computational Methods for Periodic Systems - An Overview

, 2001
We present an up-to-date survey of numerical methods for the analysis and design of linear discrete-time periodic systems. The basic tool is the periodic Schur form and its variants, for which a certain form of numerical stability can be ...
IFAC Workshop on Periodic Control Systems (PSYCO 2001), Dooren, Paul Van, Varga, Andras, Van Dooren, Paul   +3 more
core  

Constrained optimal control theory for differential linear repetitive processes

, 2008
Differential repetitive processes are a distinct class of continuous-discrete two-dimensional linear systems of both systems theoretic and applications interest.
Eric Rogers, Rogers, E., Krzysztof Galkowski, Dymkou, S., Galkowski, K., Dymkov, M., Michael Dymkov, Siarhei Dymkou   +7 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source