Results 81 to 90 of about 64,259 (224)

Evaluation of the rational prescription of linezolid, the prevalence of thrombocytopenia and major drug interactions in patients with cardiovascular diseases: are there any cautions?

Journal of Pharmacy & Pharmaceutical Sciences
The present study evaluated the rational prescription of linezolid, the prevalence of thrombocytopenia, and major drug interactions in patients with cardiovascular diseases. We conducted a retrospective cross-sectional study on linezolid-treated patients
Mehrnoush Dianatkhah, Mehrnoush Dianatkhah, Hamed Salami, Rasool Soltani, Alireza Hosseini   +4 more
doaj   +1 more source

Risk factors and outcome associated with the acquisition of linezolid-resistant Enterococcus faecalis

Journal of Global Antimicrobial Resistance, 2020
Objectives: Linezolid is a synthetic oxazolidinone antibiotic frequently used to treat vancomycin-resistant enterococcal infections. Vancomycin-susceptible Enterococcus faecalis can develop resistance to linezolid in environments with excessive linezolid
Eduardo Rodríguez-Noriega, Natalia Hernández-Morfin, Elvira Garza-Gonzalez, Paola Bocanegra-Ibarias, Samantha Flores-Treviño, Sergio Esparza-Ahumada, Esteban González-Díaz, Héctor Raúl Pérez-Gómez, Christian Mendoza-Mujica, Gerardo León-Garnica, Rayo Morfín-Otero   +10 more
doaj   +1 more source

Can we prevent antimicrobial resistance by using antimicrobials better? [PDF]

, 2013
Since their development over 60 years ago, antimicrobials have become an integral part of healthcare practice worldwide. Recently, this has been put in jeopardy by the emergence of widespread antimicrobial resistance, which is one of the major problems ...
Brown, Caron, Cars, Cars, Collignon, Dagan, DiNubile, Drlica, Essack, Fox, Geli, Goren, Gould, Guillemot, Harris, Hurdle, Huttner, Isha, Madurell, Masterton, Michalsen, Mitchison, Mitchison, Molstad, Sharma, Solapure, Talbot, Thomas   +27 more
core   +2 more sources

Factorial design and post-antibiotic sub-MIC effects of linezolid combined with fosfomycin against vancomycin-resistant enterococci [PDF]

, 2021
Yisong Yan, Yang Guang, Yaowen Li, Jun Mao, Shuaishuai Wang, Na Zhang, Huiping Liu, Xiaohui Huang   +7 more
openalex   +1 more source

Multifunctional Bioactive Coatings Based on Bioglass, Vitamin D3, and Melittin Deposited via MAPLE for Enhanced Osseointegration, Antibacterial Activity, and Corrosion Resistance of Titanium Implants

Advanced Materials Interfaces, Volume 12, Issue 22, November 22, 2025.
Matrix‐Assisted Pulsed Laser Evaporation (MAPLE) technique is used to cover titanium (Ti) substrates with multifunctional bioactive coatings composed of bioglass, vitamin D3, and melittin. Coatings exhibited excellent chemical integrity and favorable micro/nanostructured morphology (promoting cellular adhesion and viability), and a sustained release of
Irina Negut, Bogdan Bita, Mihaela Dinu, Anca Constantina Parau, Tatiana Tozar, Oana Gherasim, Valentina Grumezescu, Carmen Ristoscu, Luminita Marutescu, Gratiela Gradisteanu Pircalabioru   +9 more
wiley   +1 more source

Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first‐in‐human, Phase 1b, open‐label, single‐dose study

JOR Spine
Background Bacterial infection of the intervertebral disc is difficult to treat because the tissue is usually not vascularized and systemic antibiotic therapy may not reach optimal antibacterial exposure.
Shiva S. Tripathi, Robert Sneath, Aprajay Golash, Parag Desai, Duncan McHale, Sarah Guest, Charlie Brindley, Paul Cummings, Shane Smith, Conrad Stroud, Graham Scott, Steve Ruston, Lloyd Czaplewski   +12 more
doaj   +1 more source

Influence of real-world characteristics on outcomes for patients with methicillin-resistant Staphylococcal skin and soft tissue infections:a multi-country medical chart review in Europe [PDF]

, 2014
BACKGROUND: Patient-related (demographic/disease) and treatment-related (drug/clinician/hospital) characteristics were evaluated as potential predictors of healthcare resource use and opportunities for early switch (ES) from intravenous (IV)-to-oral ...
A Gray, AD Tice, AL Chapman, BA Cunha, BA Lipsky, C Eckmann, C Eckmann, Caitlyn T Solem, Christian Eckmann, Cynthia Macahilig, D Nathwani, D Nathwani, DA Goff, Damien Simoneau, Dilip Nathwani, HS Sader, HT Hatoum, J Edelsberg, Jennifer M Stephens, Jim Z Li, KB Bamford, M Borner, M Desai, M Dryden, M Hensher, P Mladovsky, PC Matthews, RA Seaton, Richard Chambers, S Leekha, S Parodi, SC Lim, Seema Haider, Shelby Corman, TH Dellit, Wendy Lawson   +35 more
core   +4 more sources

Efficacy, safety, tolerability and population pharmacokinetics of tedizolid, a novel antibiotic, in Latino patients with acute bacterial skin and skin structure infections

Brazilian Journal of Infectious Diseases, 2016
Acute bacterial skin and skin structure infections are caused mainly by Gram-positive bacteria which are often treated with intravenous vancomycin, daptomycin, or linezolid, with potential step down to oral linezolid for outpatients.
Alejandro Ortiz-Covarrubias, Edward Fang, Philippe G. Prokocimer, Shawn D. Flanagan, Xu Zhu, Jose Francisco Cabré-Márquez, Toshiaki Tanaka, Julie Passarell, Jill Fiedler-Kelly, Esteban C. Nannini   +9 more
doaj   +1 more source

Disseminated Nocardia cyriacigeorgia causing pancreatitis in a haploidentical stem cell transplant recipient. [PDF]

, 2017
We report the first published case of acute pancreatitis secondary to disseminated nocardiosis in a hematopoietic stem cell transplant (HSCT) recipient on chronic immunosuppression for graft-versus-host disease (GVHD).
Chen, MD, Jason, Filicko-O\u27Hara, Joanne, Flomenberg, Phyllis, Kasner, Margaret, Pan, MD, Jonathan   +4 more
core   +3 more sources

Mechanisms of endothelial cell dysfunction in cystic fibrosis [PDF]

, 2017
Although cystic fibrosis (CF) patients exhibit signs of endothelial perturbation, the functions of the cystic fibrosis conductance regulator (CFTR) in vascular endothelial cells (EC) are poorly defined.
Anile, Marco, Cianci, Eleonora, Del Porto, Paola, Dell'Elba, Giuseppe, Di Silvestre, Sara, Evangelista, Virgilio, Guarnieri, Simone, Lanuti, Paola, Marchisio, Marco, Mari, Veronica C., Mariggiã², Maria A., Moretti, Paolo, Mucilli, Felice, Pandolfi, Assunta, Patruno, Sara, Piccoli, Antonio, Plebani, Roberto, Prioletta, Marco, Recchiuti, Antonio, Romano, Mario, Sacchetti, Silvio, Totani, Licia, Venuta, Federico   +22 more
core   +1 more source