Results 151 to 160 of about 8,342 (214)

Multi‐Omics Analysis Identifies Tryptophan Metabolism and Glycolysis as Potential Pathways Involved in the Protective Effects of Tormentic Acid Against Metabolic Associated Fatty Liver Disease

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
TA alleviates MCD diet‐induced MAFLD, and this effect is associated with alterations in tryptophan metabolism and glycolysis. ABSTRACT Metabolic associated fatty liver disease (MAFLD) has high morbidity and tragically lacks effective therapeutic remedies.
Yuanyuan Wei, Dingyi Wei, Jingyang Lu, Lulin Wei, Weijia Lin, Jinbin Wei, Xiao Ma   +6 more
wiley   +1 more source

Depression detection using deep learning and large language models from multimodalities. [PDF]

Front Digit Health
Hussain Y, Zaheer MA, Khan AM, Malik AS.
europepmc   +1 more source

Beyond Traditional Covariates: An Interpretable Machine Learning Workflow for Improved Hybrid Pharmacometric Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Model‐informed precision dosing is often constrained by the limited generalizability of traditional population pharmacokinetic models, especially in critically ill patients. A hybrid machine learning‐population pharmacokinetic framework is proposed to improve a priori pharmacokinetic predictions by integrating real‐world clinical data.
Freek J. A. Relouw, Jort J. M. T. Lokers, Tim Preijers, Sebastiaan D. T. Sassen, Natal A. W. van Riel, Birgit C. P. Koch   +5 more
wiley   +1 more source

Rethinking the diagnosis of primary progressive aphasia: current challenges and future directions. [PDF]

Front Aging Neurosci
Macoir J, Lavoie M, Duboisdindien G, Laforce R.   +3 more
europepmc   +1 more source

Catheter‐Based Therapies for Intermediate‐High Risk Pulmonary Embolism: A Protocol for a Systematic Review With Bayesian Pairwise and Network Meta‐Analyses

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Intermediate‐high risk pulmonary embolism (PE) represents a clinically challenging subgroup of acute PE, characterized by right ventricular dysfunction and increased risk of hemodynamic deterioration despite treatment with anticoagulation therapy.
Jacob Hindborg Hovmann, Thomas Skjoldborg Sornn‐Friese, Frederik Færgemann Lau, Niels Brandt, Isak Mazanti Cold, Janus C. Jakobsen, Jasmin Dam Lukoschewitz, Alasdair D. Henderson, Anne Sophie Overgaard Olesen, Jens Dahlgaard Hove, Jesper Kjærgaard, Johannes Grand   +11 more
wiley   +1 more source

Speech and Language Markers of Bipolar Disorder: Challenges and Opportunities

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Background Clinicians aspire to predict the emergence of Bipolar Disorder (BD) in a timely manner. To accomplish this, markers reflecting mental states that can be gathered non‐invasively and at large scale are needed. Here, we systematically evaluate evidence relating speech‐based markers to mood states in BD.
Farida Zaher, Jessica Ahrens, Delphine Raucher‐Chéné, Alban Voppel, Lena Palaniyappan   +4 more
wiley   +1 more source

A Conversational Platform (Okaya) for Multimodal Digital Biomarkers of Fatigue, Cognition, and Mental Health: Feasibility Observational Study. [PDF]

JMIR Form Res
So M, Sobolev M, Menvielle G.
europepmc   +1 more source

Cholesterol accumulation in monocytes is associated with the severity of diabetic complications and the efficacy of glycemic control interventions in patients with type 2 diabetes

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1379-1386, August 2026.
This study reveals that monocyte cholesterol accumulation correlates with the severity of diabetic complications and predicts post‐discharge glycemic deterioration. These findings suggest that monocytic cholesterol serves as a novel translational biomarker reflecting ‘metabolic memory’ and therapeutic resistance in patients with type 2 diabetes ...
Hideyuki Okuma, Takahiro Tsutsumi, Asako Miyazaki, Kyoichiro Tsuchiya   +3 more
wiley   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, Volume 49, Issue 8, Page 5849-5865, August 2026.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

Cross-Cultural Identification of Acoustic Voice Features for Depression: A Cross-Sectional Study of Vietnamese and Japanese Datasets. [PDF]

Bioengineering (Basel)
Le PTV, Nakamura M, Higuchi M, Vuu LTM, Huynh N, Tokuno S.   +5 more
europepmc   +1 more source