Results 151 to 160 of about 8,531 (253)

Improving the clinical trial landscape for patients with atypical variants of Alzheimer's disease: a call to action

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Patients with atypical variants of Alzheimer's disease (AD) often present at a younger age with predominantly non‐amnestic impairments and a more aggressive disease course. Historically, individuals with atypical presentations have not been included in large‐scale clinical trials, which typically focus on late‐onset, sporadic amnestic ...
Nick Corriveau‐Lecavalier, Neus Falgàs, Deepti Putcha, Jonathan Graff‐Radford, Keir X. X. Yong, Baayla D. C. Boon, Rosaleena Mohanty, Eric Westman, Colin Groot, David T. Jones, Lea T. Grinberg, Gil D. Rabinovici, Jennifer L. Whitwell, Liana G. Apostolova, Melissa E. Murray, Dustin B. Hammers, Suzanne E. Schindler, Inga Atonsdottir, Elizabeth K. Rhodus, Jonathan M. Schott, Ignacio Illán‐Gala, Ogbuagu Chukwuanugo, Jorge J. Llibre Guerra, Ruth Peters, Erin L. Abner, Carla Abdelnour, Albert Lladó, Renaud La Joie, Leonardo Cruz de Souza, Neguine Rezaii, Dror Shir, Yolande A. L. Pijenburg, Maria C. Carrillo, Bradford C Dickerson, Paul Aisen, Rik Ossenkoppele, Rema Raman   +36 more
wiley   +1 more source

Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Adverse social conditions across the life course influence brain aging and dementia, yet their compounded impact on clinical phenotypes remains underexplored, particularly in Latin America, where social inequality and dementia burden are high.
Temitope Farombi, Tiago Azzi, Agustina Legaz, David Aguillón, José Alberto Avila‐Funes, Maria Isabel Behrens, Martín Bruno, Juan Felipe Cardona, Nilton Custodio, Carolina Delgado, Stefanie Pina‐Escudero, Maria del Pilar Garavito Galofre, Marcelo Maito, Nahuel Magrath‐Guimet, Justin B. Miller, Diana Matallana, Maira Okada de Oliveira, Guido Rocatti, Elisa de Paula França Resende, Andrea Slachevsky, Leonel Takada, Olivia Wen, Lina M. Zapata‐Restrepo, Brian Lawlor, Kristine Yaffe, Kun Hu, Bruce Miller, Katherine Possin, Jennifer S. Yokoyama, Sol Fittipaldi, Adolfo M. García, Hernan Hernandez Larzabal, Hernando Santamaria‐Garcia, Enzo Tagliazzuchi, Claudia Duran‐Aniotz, Agustin Ibanez, Joaquin Migeot   +36 more
wiley   +1 more source

Efficacy of a language‐concordant community health worker intervention to improve community‐to‐clinic linkage for dementia care: results of the randomized trial PLAN

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract BACKGROUND Linkage to medical services enables timely diagnosis and treatment, yet racial/ethnic minority older adults with limited English proficiency (LEP) face substantial barriers. We tested Preparing Healthy Aging through Dementia Literacy Education and Navigation (PLAN), a language‐concordant community health worker (CHW)‐led ...
Hae‐Ra Han, Nancy Perrin, Ji‐Young Yun, Deborah Min, Simona C. Kwon, Jinhui Joo, Ji‐Young Cho, Sara Kim, Hochang Benjamin Lee   +8 more
wiley   +1 more source

Validation of linguistic markers in biologically defined prodromal AD and testing of their validity in differential diagnosis [PDF]

The early identification of prodromal Alzheimer’s disease (AD) is a pressing clinical challenge, particularly as disease-modifying therapies emerge. This thesis investigates whether semantic and linguistic features derived from speech can contribute ...
O'Malley, Ronan
core  

Midlife hypertension and late‐life cognition: weighting the LifeAfter90 study

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Midlife hypertension is a well‐established predictor of late‐life cognitive decline; however, few population‐representative estimates of this association exist among oldest‐old cohorts. METHODS LifeAfter90 (LA90) is an ethnoracially diverse cohort of individuals aged 90+ linked to midlife multiphasic health check‐ups (MHC).
Hilary L. Colbeth, Joseph N. Roscoe, Maria M. Corrada, Claire C. Meunier, Kristen M. George, M. Maria Glymour, Paola Gilsanz, Rachel A. Whitmer   +7 more
wiley   +1 more source

Explainable Patient-Level Cognitive Impairment Screening via Temporal, Semantic, and Psycholinguistic Multimodal AI. [PDF]

J Intell
Abdullah, Fatima Z, Ruiz MJT, Espinosa-Sosa O, Sánchez-Mejorada CG, Téllez RQ, Rodríguez JLO, Sidorov G.   +7 more
europepmc   +1 more source

Development and Validation of a Short Version Eye‐Tracking Paradigm for the Screening and Diagnosis of Autism Spectrum Disorder in Qatar

Autism Research, Volume 19, Issue 6, June 2026.
ABSTRACT Objective behavioral assessments for autism spectrum disorder (ASD) are often time‐intensive and require substantial clinical expertise. Eye‐tracking–based paradigms offer quantifiable measures of social attention that can complement traditional tools.
Fouad Al Shaban, Iman Ghazal, Fatema Al‐Faraj, Sarah Aqel, I. Richard Thompson   +4 more
wiley   +1 more source

Digital biomarkers in the diagnosis of social anxiety disorder: a scoping review. [PDF]

BMC Psychiatry
Qiao FQ, Dong WQ, Wang XN, Sun Q.
europepmc   +1 more source

Sleep Disturbances Among Yazidi Survivors of the ISIS Genocide: Epidemiology, Neuropsychology, and Culturally Sensitive Interventions

Brain and Behavior, Volume 16, Issue 6, June 2026.
The figure presents an integrative model of sleep disturbances among Yazidi survivors of the 2014 genocide perpetrated by the Islamic State (ISIS). Genocide‐related trauma, including mass violence, sexual violence, displacement, and historical trauma, is associated with sustained neurobiological dysregulation, including hypothalamic–pituitary–adrenal ...
Jan Ilhan Kizilhan, Zelal Ag, Qanta A. Ahmed, Alon Y. Avidan   +3 more
wiley   +1 more source

Advancing Alzheimer Disease Prediction With Large Language Model-Based Linguistic Feature Analysis: Development and Validation Study. [PDF]

JMIR Med Inform
Hsu MH, Hwang SY, Tsai YH, Chang YC, Liang CK, Chang CY.   +5 more
europepmc   +1 more source