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Linkage Disequilibrium Decay in Selected Cattle Breeds [PDF]

Animals
Linkage disequilibrium (LD) maps are fundamental tools for exploring the genetic basis of traits of interest in any species. Quantifying LD patterns in cattle breeds has been made possible due to the availability of huge quantities of SNPs through modern
Farhad Bordbar, Just Jensen, Armughan Ahmed Wadood, Zipei Yao   +3 more
doaj   +2 more sources

Structural variants in linkage disequilibrium with GWAS-significant SNPs [PDF]

Heliyon
With the recent expansion of structural variant identification in the human genome, understanding the role of these impactful variants in disease architecture is critically important.
Hao Liang, Joni C. Sedillo, Steven J. Schrodi, Akihiro Ikeda   +3 more
doaj   +2 more sources

Whole Genome Linkage Disequilibrium and Effective Population Size in a Coho Salmon (Oncorhynchus kisutch) Breeding Population Using a High-Density SNP Array

Frontiers in Genetics, 2019
The estimation of linkage disequilibrium between molecular markers within a population is critical when establishing the minimum number of markers required for association studies, genomic selection, and inferring historical events influencing different ...
Agustín Barría, Kris A Christensen, Grazyella M Yoshida   +2 more
exaly   +3 more sources

Linkage Disequilibrium in Humans: Models and Data [PDF]

American Journal of Human Genetics, 2001
In this review, we describe recent empirical and theoretical work on the extent of linkage disequilibrium (LD) in the human genome, comparing the predictions of simple population-genetic models to available data.
Jonathan K. Pritchard, Molly Przeworski
openalex   +2 more sources

The Genetic Architecture of Juvenile Growth Traits in the Conifer Torreya grandis as Revealed by Joint Linkage and Linkage Disequilibrium Mapping

Frontiers in Plant Science, 2022
Despite its high economical and ornamental values, Torreya grandis, a dioecious non-timber coniferous species, has long been an underrepresented species.
Wenchong Chen, Weiwu Yu, Ang Dong, Yanru Zeng, Huwei Yuan, Bingsong Zheng, Rongling Wu, Rongling Wu   +7 more
doaj   +1 more source

Visualization of pairwise and multilocus linkage disequilibrium structure using latent forests. [PDF]

PLoS ONE, 2011
Linkage disequilibrium study represents a major issue in statistical genetics as it plays a fundamental role in gene mapping and helps us to learn more about human history.
Raphaël Mourad, Christine Sinoquet, Christian Dina, Philippe Leray   +3 more
doaj   +1 more source

Linkage Disequilibrium between LDLR rs688 and AvaII Genes and its Significant Association with Ischemic Stroke

Journal of Integrative Neuroscience, 2023
Background: To analyze the polymorphism distribution of low density lipoprotein receptor rs688, AvaII, NcoI gene in ischemic stroke, and explore the linkage disequilibrium among them. The correlation between the linkage disequilibrium and ischemic stroke
Yabin Chen, Hehui Cai, Jianming Zhang, Yongfa Su, Yibo Wu, Zhenzhong Lin, Zhishan Zhang   +6 more
doaj   +1 more source

LDlinkR: An R Package for Rapidly Calculating Linkage Disequilibrium Statistics in Diverse Populations

Frontiers in Genetics, 2020
Genomic research involving human genetics and evolutionary biology relies heavily on linkage disequilibrium (LD) to investigate population-specific genetic structure, functionally map regions of disease susceptibility and uncover evolutionary history ...
Timothy A. Myers, S. Chanock, M. Machiela   +2 more
semanticscholar   +1 more source

Recent demographic history inferred by high-resolution analysis of linkage disequilibrium.

Molecular biology and evolution, 2020
Inferring changes in effective population size (Ne) in the recent past is of special interest for conservation of endangered species and for human history research. Current methods for estimating the very recent historical Ne are unable to detect complex
E. Santiago, Irene Novo, A. Pardiñas, M. Saura, Jinliang Wang, A. Caballero   +5 more
semanticscholar   +1 more source

LDBlockShow: a fast and convenient tool for visualizing linkage disequilibrium and haplotype blocks based on variant call format files

bioRxiv, 2020
The triangular correlation heatmap aiming to visualize the linkage disequilibrium (LD) pattern and haplotype block structure of SNPs is ubiquitous component of population-based genetic studies. However, current tools suffered from the problem of time and
Shanshan Dong, Wei-Ming He, Jing-Jing Ji, Chi Zhang, Yan Guo, Tie-Lin Yang   +5 more
semanticscholar   +1 more source