Results 1 to 10 of about 177,696 (251)
Optimal linkage disequilibrium splitting. [PDF]
Bioinformatics, 2021 AbstractMotivationA few algorithms have been developed for splitting the genome in nearly independent blocks of linkage disequilibrium. Due to the complexity of this problem, these algorithms rely on heuristics, which makes them suboptimal.ResultsHere, we develop an optimal solution for this problem using dynamic programming.AvailabilityThis is now ...
Privé F.
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Division of linkage disequilibrium between absolute linkage disequilibrium and linkage equilibrium [PDF]
Journal of Human Genetics, 2005 Linkage disequilibrium is the association between alleles in the allele distributions across linked loci and is intermediate in character between the dependence and the independence of allele distribution. This ambivalence makes linkage disequilibrium difficult to understand and to treat mathematically.
Shin-ichi Kuno, Shin-ichi Kuno
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THE DIRECTION OF LINKAGE DISEQUILIBRIUM [PDF]
Genetics, 1974 ABSTRACT The previous paper (LANGLEYT,O BARanId KOJIMA 1974) reports that the directional linkage disequilibria, Dw = PABPab-PAbPaB, tend to be negative for data between allozymes and linked to inversions. A and B stand for the two alleles with the greatest frequency in the population. In this paper we show that linkage disequilibrium in
Charles H. Langley, James F. Crow
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Homozygosity and Linkage Disequilibrium [PDF]
Genetics, 2002 AbstractWe illustrate how homozygosity of haplotypes can be used to measure the level of disequilibrium between two or more markers. An excess of either homozygosity or heterozygosity signals a departure from the gametic phase equilibrium: We describe the specific form of dependence that is associated with high (low) homozygosity and derive various ...
Neil Risch, Chiara Sabatti
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The Lowdown on Linkage Disequilibrium [PDF]
The Plant Cell, 2003 Flowering time varies among Arabidopsis accessions. Some of the genes that contribute to this polygenic trait have been localized using quantitative trait loci (QTL) mapping, eventually leading to the identification of genetic variants that contribute to observed differences in flowering time ([El-
Brandon S. Gaut, Anthony D. Long
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Volume measures for linkage disequilibrium [PDF]
BMC Genetics, 2006 Abstract Background Defining measures of linkage disequilibrium (LD) that have good small sample properties and are applicable to multiallelic markers poses some challenges. The potential of volume measures in this context has been noted before, but their use has been hampered by computational challenges.
Chen, Yuguo +2 more
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Bayesian estimates of linkage disequilibrium [PDF]
BMC Genetics, 2007 The maximum likelihood estimator of D'--a standard measure of linkage disequilibrium--is biased toward disequilibrium, and the bias is particularly evident in small samples and rare haplotypes.This paper proposes a Bayesian estimation of D' to address this problem.
Sebastiani, Paola, Abad-Grau, María M.
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Positional Cloning by Linkage Disequilibrium [PDF]
The American Journal of Human Genetics, 2004 Recently, metric linkage disequilibrium (LD) maps that assign an LD unit (LDU) location for each marker have been developed (Maniatis et al. 2002). Here we present a multiple pairwise method for positional cloning by LD within a composite likelihood framework and investigate the operating characteristics of maps in physical units (kb) and LDU for two ...
Maniatis, Nikolas +5 more
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Linkage Disequilibrium in the Domesticated Pig [PDF]
Genetics, 2004 Abstract This study investigated the extent of linkage disequilibrium (LD) in two genomic regions (on chromosomes 4 and 7) in five populations of domesticated pigs. LD was measured with D′ and tested for significance with the Fisher exact test.
Nsengimana, J +3 more
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Cosmopolitan linkage disequilibrium maps [PDF]
Human Genomics, 2005 Linkage maps have been invaluable for the positional cloning of many genes involved in severe human diseases. Standard genetic linkage maps have been constructed for this purpose from the Centre d'Etude du Polymorphisme Humain and other panels, and have been widely used.
Gibson, Jane +4 more
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