Results 1 to 10 of about 199,519 (335)
Optimal linkage disequilibrium splitting [PDF]
Bioinformatics, 2021 Abstract Motivation A few algorithms have been developed for splitting the genome in nearly independent blocks of linkage disequilibrium. Due to the complexity of this problem, these algorithms rely on heuristics, which makes them suboptimal.
Privé F.
openaire +5 more sources
Cosmopolitan linkage disequilibrium maps [PDF]
Human Genomics, 2005 Linkage maps have been invaluable for the positional cloning of many genes involved in severe human diseases. Standard genetic linkage maps have been constructed for this purpose from the Centre d'Etude du Polymorphisme Humain and other panels, and have ...
Gibson Jane +4 more
doaj +4 more sources
Volume measures for linkage disequilibrium [PDF]
BMC Genetics, 2006 Background Defining measures of linkage disequilibrium (LD) that have good small sample properties and are applicable to multiallelic markers poses some challenges. The potential of volume measures in this context has been noted before, but their use has
Lin Chia-Ho, Chen Yuguo, Sabatti Chiara
doaj +5 more sources
Association testing strategy for data from dense marker panels. [PDF]
PLoS ONE, 2013 Genome wide association studies have been usually analyzed in a univariate manner. The commonly used univariate tests have one degree of freedom and assume an additive mode of inheritance.
Donghyung Lee, Silviu-Alin Bacanu
doaj +6 more sources
Linkage disequilibrium in wild mice. [PDF]
PLoS Genetics, 2007 Crosses between laboratory strains of mice provide a powerful way of detecting quantitative trait loci for complex traits related to human disease. Hundreds of these loci have been detected, but only a small number of the underlying causative genes have ...
Cathy C Laurie +8 more
doaj +4 more sources
Structural variants in linkage disequilibrium with GWAS-significant SNPs [PDF]
HeliyonWith the recent expansion of structural variant identification in the human genome, understanding the role of these impactful variants in disease architecture is critically important.
Hao Liang +3 more
doaj +2 more sources
Mapping Genes through the Use of Linkage Disequilibrium Generated by Genetic Drift: ‘Drift Mapping’ in Small Populations with No Demographic Expansion [PDF]
, 1998 Linkage disequilibrium has been a powerful tool in identifying rare disease alleles in human populations. To date, most research has been directed to isolated populations which have undergone a bottleneck followed by rapid exponential expansion.
Joseph D. Terwilliger +3 more
openalex +4 more sources
Assortative Mating and Linkage Disequilibrium [PDF]
G3: Genes, Genomes, Genetics, 2017 Assortative mating has been suggested to result in an increase in heritability and additive genetic variance through an increase in linkage disequilibrium.
Philip W. Hedrick
doaj +4 more sources
Linkage Disequilibrium Decay in Selected Cattle Breeds [PDF]
AnimalsLinkage disequilibrium (LD) maps are fundamental tools for exploring the genetic basis of traits of interest in any species. Quantifying LD patterns in cattle breeds has been made possible due to the availability of huge quantities of SNPs through modern
Farhad Bordbar +3 more
doaj +2 more sources
Long-range linkage disequilibrium in French beef cattle breeds [PDF]
Genetics Selection Evolution, 2021 Background Linkage disequilibrium (LD) is a key parameter to study the history of populations and to identify and fine map quantitative trait loci (QTL) and it has been studied for many years in animal populations.
Abdelmajid El Hou +4 more
doaj +2 more sources