Results 1 to 10 of about 105,176 (151)
Optimal linkage disequilibrium splitting. [PDF]
Bioinformatics, 2021 Abstract Motivation A few algorithms have been developed for splitting the genome in nearly independent blocks of linkage disequilibrium. Due to the complexity of this problem, these algorithms rely on heuristics, which makes them suboptimal.
Privé F.
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Cosmopolitan linkage disequilibrium maps [PDF]
Human Genomics, 2005 Linkage maps have been invaluable for the positional cloning of many genes involved in severe human diseases. Standard genetic linkage maps have been constructed for this purpose from the Centre d'Etude du Polymorphisme Humain and other panels, and have ...
Gibson Jane +4 more
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Volume measures for linkage disequilibrium [PDF]
BMC Genetics, 2006 Background Defining measures of linkage disequilibrium (LD) that have good small sample properties and are applicable to multiallelic markers poses some challenges. The potential of volume measures in this context has been noted before, but their use has
Lin Chia-Ho, Chen Yuguo, Sabatti Chiara
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Linkage disequilibrium in wild mice. [PDF]
PLoS Genetics, 2007 Crosses between laboratory strains of mice provide a powerful way of detecting quantitative trait loci for complex traits related to human disease. Hundreds of these loci have been detected, but only a small number of the underlying causative genes have ...
Cathy C Laurie +8 more
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Structural variants in linkage disequilibrium with GWAS-significant SNPs [PDF]
HeliyonWith the recent expansion of structural variant identification in the human genome, understanding the role of these impactful variants in disease architecture is critically important.
Hao Liang +3 more
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Assortative Mating and Linkage Disequilibrium [PDF]
G3: Genes, Genomes, Genetics, 2017 Assortative mating has been suggested to result in an increase in heritability and additive genetic variance through an increase in linkage disequilibrium.
Philip W. Hedrick
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Linkage Disequilibrium Decay in Selected Cattle Breeds [PDF]
AnimalsLinkage disequilibrium (LD) maps are fundamental tools for exploring the genetic basis of traits of interest in any species. Quantifying LD patterns in cattle breeds has been made possible due to the availability of huge quantities of SNPs through modern
Farhad Bordbar +3 more
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Incorporating additive genetic effects and linkage disequilibrium information to discover gene-environment interactions using BV-LDER-GE [PDF]
Genome BiologyUncovering environmental factors interacting with genetic factors to influence complex traits is important in genetic epidemiology and disease etiology. We introduce BiVariate Linkage-Disequilibrium Eigenvalue Regression for Gene-Environment interactions
Zihan Dong +6 more
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Frontiers in Plant Science, 2022 Despite its high economical and ornamental values, Torreya grandis, a dioecious non-timber coniferous species, has long been an underrepresented species.
Wenchong Chen +7 more
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Visualization of pairwise and multilocus linkage disequilibrium structure using latent forests. [PDF]
PLoS ONE, 2011 Linkage disequilibrium study represents a major issue in statistical genetics as it plays a fundamental role in gene mapping and helps us to learn more about human history.
Raphaël Mourad +3 more
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