Results 11 to 20 of about 537,873 (344)
Linkage disequilibrium in wild mice. [PDF]
PLoS Genetics, 2007 Crosses between laboratory strains of mice provide a powerful way of detecting quantitative trait loci for complex traits related to human disease. Hundreds of these loci have been detected, but only a small number of the underlying causative genes have ...
Cathy C Laurie +8 more
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Cosmopolitan linkage disequilibrium maps [PDF]
Human Genomics, 2005 Linkage maps have been invaluable for the positional cloning of many genes involved in severe human diseases. Standard genetic linkage maps have been constructed for this purpose from the Centre d'Etude du Polymorphisme Humain and other panels, and have ...
Gibson Jane +4 more
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Volume measures for linkage disequilibrium [PDF]
BMC Genetics, 2006 Background Defining measures of linkage disequilibrium (LD) that have good small sample properties and are applicable to multiallelic markers poses some challenges. The potential of volume measures in this context has been noted before, but their use has
Lin Chia-Ho, Chen Yuguo, Sabatti Chiara
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Assortative Mating and Linkage Disequilibrium [PDF]
G3: Genes, Genomes, Genetics, 2017 Assortative mating has been suggested to result in an increase in heritability and additive genetic variance through an increase in linkage disequilibrium.
Philip W. Hedrick
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Bayesian estimates of linkage disequilibrium [PDF]
BMC Genetics, 2007 Background The maximum likelihood estimator of D' – a standard measure of linkage disequilibrium – is biased toward disequilibrium, and the bias is particularly evident in small samples and rare haplotypes.
Abad-Grau María M, Sebastiani Paola
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Genotype determination for polymorphisms in linkage disequilibrium [PDF]
BMC Bioinformatics, 2009 Background Genome-wide association studies with single nucleotide polymorphisms (SNPs) show great promise to identify genetic determinants of complex human traits.
Anton-Culver Hoda +4 more
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Linkage disequilibrium and genetic variability [PDF]
Genetical Research, 1974 SUMMARYIt has been shown previously that, even in the absence of linkage, selection can cause an appreciable change in the genetic variance of a metric character due to disequilibrium; this change is temporary and is rapidly reversed when selection ceases.
M. G. Bulmer
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Structure of linkage disequilibrium in plants. [PDF]
Annual Review of Plant Biology, 2003 Future advances in plant genomics will make it possible to scan a genome for polymorphisms associated with qualitative and quantitative traits. Before this potential can be realized, we must understand the nature of linkage disequilibrium (LD) within a ...
S. Flint-Garcia +2 more
semanticscholar +4 more sources
Optimal linkage disequilibrium splitting. [PDF]
Bioinformatics, 2021 AbstractMotivationA few algorithms have been developed for splitting the genome in nearly independent blocks of linkage disequilibrium. Due to the complexity of this problem, these algorithms rely on heuristics, which makes them suboptimal.ResultsHere, we develop an optimal solution for this problem using dynamic programming.AvailabilityThis is now ...
Privé F.
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LINKAGE DISEQUILIBRIUM IN SUBDIVIDED POPULATIONS [PDF]
Genetics, 1973 ABSTRACT The linkage disequilibrium in a subdivided populaton is shown to be equal to the sum of the average linkage disequilibrium for all subpopulations and the covariance between gene frequencies of the loci concerned. Thus, in a subdivided population the linkage disequilibrium may not be 0 even if the linkage disequilibrium in each ...
Masatoshi Nei, Wen‐Hsiung Li
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