Results 11 to 20 of about 177,696 (251)

Assortative Mating and Linkage Disequilibrium [PDF]

G3 Genes|Genomes|Genetics, 2017
AbstractAssortative mating has been suggested to result in an increase in heritability and additive genetic variance through an increase in linkage disequilibrium. The impact of assortative mating on linkage disequilibrium was explicitly examined for the two-locus model of Wright (1921) and two selective assortative mating models. For the Wright (1921)
openaire   +8 more sources

Plasmodium falciparum: linkage disequilibrium between loci in chromosomes 7 and 5 and chloroquine selective pressure in Northern Nigeria. [PDF]

, 2001
In view of the recent discovery (Molecular Cell 6, 861-871) of a (Lys76Thr) codon change in gene pfcrt on chromosome 7 which determines in vitro chloroquine resistance in Plasmodium falciparum, we have re-examined samples taken before treatment in our ...
Boko, Pelagie, Dadzie, Samuel, Djogbenou, Luc, Donnelly, Martin, Dowd, Andrew, Jenkins, Adam M., Lu, Fang, Mayans, Olga, Mitchell, Sara N., Muskavitch, Marc A. T., Paine, Mark, Ranson, Hilary, Regna, Kimberly, Rigden, Daniel J., Weetman, David, Wilding, Craig S.   +15 more
core   +18 more sources

Single nucleotide polymorphisms in the CDH18 gene affect growth traits in Hu sheep

Animal Research and One Health, EarlyView., 2023
Abstract Growth traits are critical economic traits in sheep. Genetic polymorphism has a great influence on the improvement of sheep traits. The aim of this study was to analyze the effect of cadherin 18 (CDH18) gene polymorphisms on growth traits in Hu sheep.
Tianyi Liu, Yazhen Bi, Jingjing Bao, Mingyu Shang, Wenping Hu, Li Zhang   +5 more
wiley   +1 more source

Confounding by linkage disequilibrium [PDF]

Journal of Human Genetics, 2013
Linkage disequilibrium (LD) and confounding are two widely discussed concepts in Genetics and in Epidemiology, yet their relationship has received only intuitive or no considerations. Taken in the narrow sense, LD refers to the nonrandom association of alleles at two or more linked genetic loci.
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Testing Linkage Disequilibrium in Sibships [PDF]

The American Journal of Human Genetics, 2000
We describe the use of multivariate regression for testing allelic association in the presence of linkage, using marker genotype data from sibships. The test is valid, provided that the correct mean structure is modeled but does not require the correlation structure within families to be specified. The test can be implemented using standard statistical
Peter Kraft, Bryan Langholz, Duncan C. Thomas, Kimberly D. Siegmund   +3 more
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Mapping genes through the use of linkage disequilibrium generated by genetic drift: 'Drift mapping' in small populations with no demographic expansion [PDF]

, 1998
Linkage disequilibrium has been a powerful tool in identifying rare disease alleles in human populations. To date, most research has been directed to isolated populations which have undergone a bottleneck followed by rapid exponential expansion.
Laan, Maris, Pääbo, Svante, Terwilliger, Joseph D., Zöllner, Sebastian   +3 more
core   +1 more source

Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study [PDF]

, 2005
Juvenile rheumatoid arthritis (JRA) comprises a group of chronic systemic inflammatory disorders that primarily affect joints and can cause long-term disability.
Bukulmez, H, Colbert, RA, Elston, RC, Fife, M, Glass, DN, Olson, JM, Thompson, SD, Tsoras, M, Twine, NA, Woo, P   +9 more
core   +2 more sources

Genomic signatures of population decline in the malaria mosquito Anopheles gambiae [PDF]

, 2016
Population genomic features such as nucleotide diversity and linkage disequilibrium are expected to be strongly shaped by changes in population size, and might therefore be useful for monitoring the success of a control campaign.
A De, AD Stump, Austin Burt, CG Nevill, Charles Mbogo, D Bachtrog, EA Okiro, F Tajima, F Tajima, Franklin Mosha, G McVean, GA Watterson, H Li, H Li, H Li, Janet Midega, JH Gillespie, JK Pritchard, JM Mwangangi, K Tamura, K Thornton, KA Lindblade, M Kirin, M Pombi, MN Bayoh, NJ Govella, P Andolfatto, PC Kipyab, PP Chaki, PR Haddrill, RF Daniels, RN Gutenkunst, RR Hudson, S Schiffels, Samantha M. O’Loughlin, SC Nkhoma, SM O’Loughlin, Stephen M. Magesa, TL Russell, WG Hill   +39 more
core   +5 more sources

Genome resequencing reveals multiscale geographic structure and extensive linkage disequilibrium in the forest tree Populus trichocarpa [PDF]

, 2009
This is the publisher’s final pdf. The article is copyrighted by the New Phytologist Trust and published by John Wiley & Sons, Inc. It can be found at: http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291469-8137.
Slavov, Gancho Trifonu, Difazio, Stephen P., Martin, Joel, Schackwitz, Wendy, Muchero, Wellington, Rodgers-Melnick, Eli, Lipphardt, Mindie F., Pennacchio, Christa P., Hellsten, Uffe, Pennacchio, Len A., Gunter, Lee E., Ranjan, Priya, Vining, Kelly, Pomraning, Kyle R., Wilhelm, Larry J., Pellegrini, Matteo, Mockler, Todd C., Freitag, Michael, Geraldes, Armando, El-Kassaby, Yousry A., Mansfield, Shawn D., Cronk, Quentin C. B., Douglas, Carl J., Strauss, Steven H., Rokhsar, Dan, Tuskan, Gerald A.   +25 more
core   +4 more sources

Linkage Disequilibrium in Domestic Sheep [PDF]

Genetics, 2002
Abstract The last decade has seen a dramatic increase in the number of livestock QTL mapping studies. The next challenge awaiting livestock geneticists is to determine the actual genes responsible for variation of economically important traits.
McRae, AF, McEwan, JC, Dodds, KG, Wilson, T, Crawford, AM, Slate, J   +5 more
openaire   +3 more sources