Co-selection of the H63D mutation and the HLA-A29 allele: a new paradigm of linkage disequilibrium? [PDF]
, 2002 The major histocompatibility complex (MHC) shows a remarkable conservation of particular HLA antigens and haplotypes in linkage disequilibrium in most human populations, suggesting the existence of a convergent evolution.
Alves, H. +8 more
core +1 more source
The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem [PDF]
, 2016 Several important and fundamental aspects of disease genetics models have yet to be described. One such property is the relationship of disease association statistics at a marker site closely linked to a disease causing site.
Bansal, Naveen K. +8 more
core +3 more sources
Extent and structure of linkage disequilibrium in canola quality winter rapeseed (Brassica napus L.) [PDF]
, 2009 Linkage disequilibrium was investigated in canola quality winter rapeseed to analyze (1) the prospects for whole-genome association analyses and (2) the impact of the recent breeding history of rapeseed on linkage disequilibrium.
A Darvasi +39 more
core +2 more sources
Linkage disequilibrium in wild mice
PLoS Genetics, 2005 Crosses between laboratory strains of mice provide a powerful way of detecting quantitative trait loci for complex traits related to human disease. Hundreds of these loci have been detected, but only a small number of the underlying causative genes have been identified.
Bruce S. Weir +8 more
openaire +5 more sources
Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Hepatology, EarlyView., 2022 Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren +4 more
wiley +1 more source
Handling linkage disequilibrium in linkage analysis using dense single-nucleotide polymorphisms [PDF]
, 2007 The presence of linkage disequilibrium violates the underlying assumption of linkage equilibrium in most traditional multipoint linkage approaches. Studies have shown that such violation leads to bias in qualitative trait linkage analysis when parental ...
Cho, Kelly, Dupuis, Josée, Yang, Qiong
core +6 more sources
Robust Tests in Genome-Wide Scans under Incomplete Linkage Disequilibrium [PDF]
, 2009 Under complete linkage disequilibrium (LD), robust tests often have greater power than Pearson's chi-square test and trend tests for the analysis of case-control genetic association studies.
Geller, Nancy +4 more
core +1 more source
QTL detection for a medium density SNP panel: comparison of different LD and LA methods [PDF]
, 2010 Background: New molecular technologies allow high throughput genotyping for QTL mapping with dense genetic maps. Therefore, the interest of linkage analysis models against linkage disequilibrium could be questioned.
Bacciu, Nicola +3 more
core +2 more sources
Transient Linkage Disequilibrium in Drosophila
Nature, 1971 Uploaded by Plazi for TaxoDros. We do not have abstracts.
O'Brien, Stephen J., MacIntyre, Ross J.
openaire +5 more sources
Genetic diversity and linkage disequilibrium using SNP (KASP) and AFLP markers in a worldwide durum wheat (Triticum turgidum L. Var durum) collection [PDF]
, 2019 The aim of this work was to analyze the genetic diversity and linkage disequilibrium in a collection of 168 durum wheat accessions (Triticum turgidum L. var. durum) of different origins.
Beaufort, Valeria +4 more
core +1 more source