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Division of linkage disequilibrium between absolute linkage disequilibrium and linkage equilibrium [PDF]
Journal of Human Genetics, 2005 Linkage disequilibrium is the association between alleles in the allele distributions across linked loci and is intermediate in character between the dependence and the independence of allele distribution. This ambivalence makes linkage disequilibrium difficult to understand and to treat mathematically.
Shin-ichi Kuno, Shin-ichi Kuno
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THE DIRECTION OF LINKAGE DISEQUILIBRIUM [PDF]
Genetics, 1974 ABSTRACT The previous paper (LANGLEYT,O BARanId KOJIMA 1974) reports that the directional linkage disequilibria, Dw = PABPab-PAbPaB, tend to be negative for data between allozymes and linked to inversions. A and B stand for the two alleles with the greatest frequency in the population. In this paper we show that linkage disequilibrium in
Charles H. Langley, James F. Crow
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Homozygosity and Linkage Disequilibrium [PDF]
Genetics, 2002 AbstractWe illustrate how homozygosity of haplotypes can be used to measure the level of disequilibrium between two or more markers. An excess of either homozygosity or heterozygosity signals a departure from the gametic phase equilibrium: We describe the specific form of dependence that is associated with high (low) homozygosity and derive various ...
Neil Risch, Chiara Sabatti
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The Lowdown on Linkage Disequilibrium [PDF]
The Plant Cell, 2003 Flowering time varies among Arabidopsis accessions. Some of the genes that contribute to this polygenic trait have been localized using quantitative trait loci (QTL) mapping, eventually leading to the identification of genetic variants that contribute to observed differences in flowering time ([El-
Brandon S. Gaut, Anthony D. Long
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LDtrait: An Online Tool for Identifying Published Phenotype Associations in Linkage Disequilibrium
Cancer Research, 2020 The new GWAS search tool LDtrait will expedite discovery of shared genetic components underlying seemingly unrelated diseases and may offer novel insights into cancer research.
Shu-Hong Lin +2 more
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On the Extent of Linkage Disequilibrium in the Genome of Farm Animals
Frontiers in Genetics, 2020 Given the importance of linkage disequilibrium (LD) in gene mapping and evolutionary inferences, I characterize in this review the pattern of LD and discuss the influence of human intervention during domestication, breed establishment, and subsequent ...
S. Qanbari
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Disequilibrium linkage (gametic disequilibrium) of structural genes in the bovine population
Аграрная наука Евро-Северо-Востока, 2021 In the population of Kholmogor cattle (n=824), gametic disequilibrium was studied for alleles of the polymorphic loci β-Lg (LGB), β-Cn (CSN2) and æ-Cn (CSN3). In purebred Kholmogor cattle, the β-casein polymorphism is determined by three alleles with the
V. S. Matyukov, V. G. Zainullin
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Positional Cloning by Linkage Disequilibrium [PDF]
The American Journal of Human Genetics, 2004 Recently, metric linkage disequilibrium (LD) maps that assign an LD unit (LDU) location for each marker have been developed (Maniatis et al. 2002). Here we present a multiple pairwise method for positional cloning by LD within a composite likelihood framework and investigate the operating characteristics of maps in physical units (kb) and LDU for two ...
Maniatis, Nikolas +5 more
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Exploring linkage disequilibrium [PDF]
Molecular Ecology Resources, 2015 Linkage disequilibrium (LD, association of allelic states across loci) is poorly understood by many evolutionary biologists, but as technology for multilocus sampling improves, we ignoreLDat our peril. If we sample variation at 10 loci in an organism with 20 chromosomes, we can reasonably treat them as 10 ‘independent witnesses’ of the evolutionary ...
S. Baird
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Linkage Disequilibrium Mapping
Definitions, 2020 Linkage disequilibrium (LD) mapping is a procedure for determining the non-random association of alleles at two or more loci on a chromosome. It is based on the premise that regions adjacent to a gene of interest are transmitted through the generations ...
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