Results 31 to 40 of about 537,873 (344)
Linkage Disequilibrium in the Domesticated Pig [PDF]
Genetics, 2004 Abstract This study investigated the extent of linkage disequilibrium (LD) in two genomic regions (on chromosomes 4 and 7) in five populations of domesticated pigs. LD was measured with D′ and tested for significance with the Fisher exact test.
Nsengimana, J +3 more
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Extent of third-order linkage disequilibrium in a composite line of Iberian pigs
BMC Genetics, 2018 Background Previous studies on linkage disequilibrium have investigated second order linkage disequilibrium in animal and plant populations. The objective of this paper was to investigate the genome-wide levels of third order linkage disequilibrium in a ...
Luis Gomez-Raya +4 more
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Frontiers in Genetics, 2021 Mendelian randomization makes use of genetic variants as instrumental variables to eliminate the influence induced by unknown confounders on causal estimation in epidemiology studies.
Yuquan Wang +5 more
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Confounding by linkage disequilibrium [PDF]
Journal of Human Genetics, 2013 Linkage disequilibrium (LD) and confounding are two widely discussed concepts in Genetics and in Epidemiology, yet their relationship has received only intuitive or no considerations. Taken in the narrow sense, LD refers to the nonrandom association of alleles at two or more linked genetic loci.
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Single nucleotide polymorphisms in the CDH18 gene affect growth traits in Hu sheep
Animal Research and One Health, EarlyView., 2023 Abstract Growth traits are critical economic traits in sheep. Genetic polymorphism has a great influence on the improvement of sheep traits. The aim of this study was to analyze the effect of cadherin 18 (CDH18) gene polymorphisms on growth traits in Hu sheep.
Tianyi Liu +5 more
wiley +1 more source
Accurate Estimation of Effective Population Size in the Korean Dairy Cattle Based on Linkage Disequilibrium Corrected by Genomic Relationship Matrix [PDF]
Asian-Australasian Journal of Animal Sciences, 2013 Linkage disequilibrium between markers or genetic variants underlying interesting traits affects many genomic methodologies. In many genomic methodologies, the effective population size (Ne) is important to assess the genetic diversity of animal ...
Dong-Hyun Shin +4 more
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Testing Linkage Disequilibrium in Sibships [PDF]
The American Journal of Human Genetics, 2000 We describe the use of multivariate regression for testing allelic association in the presence of linkage, using marker genotype data from sibships. The test is valid, provided that the correct mean structure is modeled but does not require the correlation structure within families to be specified. The test can be implemented using standard statistical
Peter Kraft +3 more
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BMC Bioinformatics, 2006 Background Various software tools are available for the display of pairwise linkage disequilibrium across multiple single nucleotide polymorphisms. The HapMap project also presents these graphics within their website.
Day Ian NM +3 more
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Whole genome linkage disequilibrium maps in cattle
BMC Genetics, 2007 Background Bovine whole genome linkage disequilibrium maps were constructed for eight breeds of cattle. These data provide fundamental information concerning bovine genome organization which will allow the design of studies to associate genetic variation
Mannen Hideyuki +16 more
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A linkage disequilibrium-based approach to selecting disease-associated rare variants.
PLoS ONE, 2013 Rare variants have increasingly been cited as major contributors in the disease etiology of several complex disorders. Recently, several approaches have been proposed for analyzing the association of rare variants with disease.
Rajesh Talluri, Sanjay Shete
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