Results 61 to 70 of about 177,696 (251)

The Trimmed-Haplotype Test for Linkage Disequilibrium [PDF]

The American Journal of Human Genetics, 2000
Single-marker linkage-disequilibrium (LD) methods cannot fully describe disequilibrium in an entire chromosomal region surrounding a disease allele. With the advent of myriad tightly linked microsatellite markers, we have an opportunity to extend LD analysis from single markers to multiple-marker haplotypes. Haplotype analysis has increased statistical
MacLean, C J, Martin, R B, Sham, P C, Wang, H, Straub, R E, Kendler, K S   +5 more
openaire   +5 more sources

Impact of slug length in gas–liquid two‐phase flow on the structural stress characteristics of horizontal rigid pipelines

The Canadian Journal of Chemical Engineering, EarlyView.
Data collection and processing of slug length in two‐phase flow‐induced stress analysis. Abstract The intermittent passage of liquid slugs and gas pockets in slug flow generates substantial cyclic stress damage to piping systems and their supports. This issue poses significant challenges to the various industries in which this flow pattern is present ...
Abdalellah O. Mohmmed, Hussain H. Al‐Kayiem, Abderraouf Arabi   +2 more
wiley   +1 more source

Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2)

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical inhibition and genetic variation of the Breast Cancer Resistance Protein (BCRP/ABCG2) efflux transporter can significantly influence drug exposure, highlighting the need for reliable BCRP functional biomarkers. This study aimed to identify and evaluate biomarkers predictive of BCRP function in humans.
Andrew M. Riselli, Sook Wah Yee, Jia Yang, Claire M. Brett, Kelsey Trumbach, Xujia Zhou, Renmeng Liu, Xiaomin Liang, Yurong Lai, Runlan Huo, Yongjun Xue, Hong Shen, Lei Zhang, Xinning Yang, Qi Liu, Shiew‐Mei Huang, Kathleen M. Giacomini   +16 more
wiley   +1 more source

Improving sequence-based genotype calls with linkage disequilibrium and pedigree information

, 2012
Whole and targeted sequencing of human genomes is a promising, increasingly feasible tool for discovering genetic contributions to risk of complex diseases.
Whittemore, Alice S., Zhou, Baiyu
core   +1 more source

Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD [PDF]

, 2009
9 pages, 2 figures, 4 additional files.[Background] It is well known that the pattern of linkage disequilibrium varies between human populations, with remarkable geographical stratification.
Bertranpetit, Jaume, Bosch, Elena, Calafell, Francesc, Casals, Ferran, Comas, David, Ferrer Admetlla, Anna, Gardner, Michelle, Graffelman, Jan, Laayouni, Hafid, Morcillo-Suárez, Carlos, Moreno Estrada, Andrés, Navarro, Arcadi, Rosa, Araceli   +12 more
core   +3 more sources

Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account

Clinical Pharmacology &Therapeutics, EarlyView.
The polymorphic CYP2D6 enzyme plays a pivotal role in the metabolism of approximately 25% of clinically prescribed drugs. However, the impact of specific genetic variants on the interindividual variability in CYP2D6‐mediated drug metabolism remains insufficiently quantified. This translational study sought to address this gap by analyzing the genotypes
Inger Johansson, Emmanouella M. Xanthopoulou, Yitian Zhou, Anabel Sanchez‐Spitman, Maaike van der Lee, Birgit M. Wollmann, Elisabet Størset, Jesse J. Swen, Henk‐Jan Guchelaar, Espen Molden, Marin M. Jukic, Magnus Ingelman‐Sundberg   +11 more
wiley   +1 more source

Pairwise Linkage Disequilibrium Estimation for Polyploids [PDF]

Molecular Ecology Resources, 2020
AbstractMany tasks in statistical genetics involve pairwise estimation of linkage disequilibrium (LD). The study of LD in diploids is mature. However, in polyploids, the field lacks a comprehensive characterization of LD. Polyploids also exhibit greater levels of genotype uncertainty than diploids, and yet no methods currently exist to estimate LD in ...
openaire   +4 more sources

Polymorphism Analysis of Genes Involved in Xenobiotic Metabolism and Circadian Rhythm in Human Breast Cancer [PDF]

, 2013
Individual response to xenobiotic exposures depends on the dynamics of xenobiotic metabolism and the circadian clock system, among other factors.
Cerliani, María Belén, Richard, Silvina Mariel   +1 more
core   +1 more source

Patterns of genetic diversity and linkage disequilibrium in a highly structured Hordeum vulgare association-mapping population for the Mediterranean basin [PDF]

, 2009
Population structure and genome-wide linkage disequilibrium (LD) were investigated in 192 Hordeum vulgare accessions providing a comprehensive coverage of past and present barley breeding in the Mediterranean basin, using 50 nuclear microsatellite and 1 ...
Akar, T., Al-Yassin, A., Benbelkacem, A., Bort, J., Ceccarelli, S., Comodran, J., Eeuwijk, F.A., van, Grando, S., Hackett, C.A., Ouabbou, H., Pecchioni, N., Romagosa, I., Russel, J.R., Stanca, A.M., Thomas, W.T.B.   +14 more
core   +2 more sources

ESR1 Variants and Subcontinental Genomic Ancestry: Insights from the 1000 Genomes Project and Native American Populations

Clinical Pharmacology &Therapeutics, EarlyView.
The ESR1 gene is relevant in breast cancer treatments in the pharmacogenetics context. However, Native, African, and mixed populations are known to be underrepresented in genomic studies. This is particularly important given that the difference in variants' frequencies among different populations can lead to population‐specific clinical implications ...
Mariana M. Scudeler, Caíque Manóchio, Bruno Miwa, Guilherme Belfort‐Almeida, Lucas Faria‐Costa, Cesar Sanchez, Carlos Padilla, Omar Caceres, Eduardo Tarazona‐Santos, Heinner Guio, Timothy D. O'Connor, Fernanda Rodrigues‐Soares   +11 more
wiley   +1 more source