Results 101 to 110 of about 6,712,199 (326)

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Die nachhaltige Bewahrung einer Forschungsdatenbank durch Linked Data. Laut welchem Vokabular?

open access: yesLibrary Ideas, 2019
Linked Data bietet die Möglichkeit nicht nur normkonforme Datensätze zur Verfügung zu stellen sonder auch nachhaltig und langfristig Metadaten zu bewahren, wenn diese zu Linked Data Vokabularen verknüpft sind. Aber welches Vokabular soll man nutzen?
Francesco Gelati
doaj   +1 more source

Linked raster data

open access: yes, 2012
Linked Data (LD) is a paradigm that allows linking various heterogeneous data sources in a well-defined way (Bizer, Heath, & Berners-Lee, 2009). These links establish a Web of Data (WoD), instead of a web of html documents. In the WoD more and more geographic data sets are made available such as GeoNames, dbPedia, etc.
Scharrenbach, Thomas   +3 more
openaire   +2 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

From Linked Data to Relevant Data -- Time is the Essence

open access: yes, 2011
The Semantic Web initiative puts emphasis not primarily on putting data on the Web, but rather on creating links in a way that both humans and machines can explore the Web of data.
Kirchberg, Markus   +2 more
core  

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

Building ontologies from folksonomies and linked data: Data structures and Algorithms [PDF]

open access: yes, 2012
We present the data structures and algorithms used in the approach for building domain ontologies from folksonomies and linked data. In this approach we extracts domain terms from folksonomies and enrich them with semantic information from the Linked ...
Corcho, Oscar   +4 more
core   +1 more source

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