Results 131 to 140 of about 2,923,830 (288)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Predictors of short-term outcomes after postoperative periprosthetic femoral fracture : a UK linked data analysis. [PDF]

Bone Jt Open
Aryaie M, Evans JT, Shelton CL, Johansen A, Smith TO, Whitehouse MR, Goodwin D, Bottle A, PROFOUND study team.   +8 more
europepmc   +1 more source

Integrating Premodern Manuscript Metadata into Wikidata: A Case Study in Ontology Design and Linked Data Reuse [PDF]

Rose A. McCandless, L. P. Coladangelo
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Perinatal relapse or recurrence rates in women reporting preconception anxiety and/or depression: a longitudinal study using linked data. [PDF]

Arch Womens Ment Health
Rae C, Leigh L, Holliday E, Chojenta C.
europepmc   +1 more source

DNA polymorphisms in inflammatory and endocrine signals linked to frailty are also associated with obesity: data from the FRASNET cohort [PDF]

Sarah Damanti, Lorena Citterio, Laura Zagato, Elena Brioni, Cristiano Magnaghi, Marco Simonini, Rebecca De Lorenzo, Mariapia Ruggiero, Simona Santoro, Eleonora Senini, Marco Messina, Giordano Vitali, Paolo Manunta, Angelo A. Manfredi, Chiara Lanzani, Patrizia Rovere‐Querini   +15 more
openalex   +1 more source

Linked Data

Theology Cataloging Bulletin, 2015
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Discovering linked data collections through a new national metadata platform. [PDF]

Int J Popul Data Sci
Miller KM, Flack FS, Smith MB, Bennett V, Marshall CE.   +4 more
europepmc   +1 more source

Uduvudu: a Graph-Aware and Adaptive UI Engine for Linked Data

, 2015
Michael Luggen, Adrian Gschwend, Bernhard Anrig, Philippe Cudré-Mauroux   +3 more
openalex   +2 more sources