Results 51 to 60 of about 1,479,186 (249)
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Using SPARQL to access Linked Open Data
The Programming Historian, 2015 This lesson explains why many cultural institutions are adopting graph databases, and how researchers can access these data though the query language called SPARQL.
Matthew Lincoln
doaj
Linked Open Data - De vijf sterren van open data
Informatie Professional, 2014 Article (in Dutch) published in Informatieprofessional magazine, 2014, issue 2. Verschenen in Informatieprofessional, jaargang 2014, nummer 2.
openaire +2 more sources
Linked Open Data Literacy for Librarians [PDF]
, 2014 Linked Data has become an important issue, not only for the process of building the web of data, but also for the mutual knowledge transfer between libraries and the web of data. Based on a study concerning Linked Open Data applications in libraries and the qualifications of future librarians involved in the development of such applications, we built a
Hügi, Jasmin, Schneider, René
openaire +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Von der Schneeflocke zur Lawine: Möglichkeiten der Nutzung freier Zitationsdaten in Bibliotheken
o-bib. Das offene Bibliotheksjournal, 2017 Zitationen spielen eine wichtige Rolle im wissenschaftlichen Diskurs, in der Recherchepraxis sowie im Bereich der Bibliometrie. In jüngster Zeit gibt es zunehmend Initiativen, die Zitationen als Open Data zur freien Nachnutzung verfügbar machen.
Annette Klein
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Matchmaking Public Procurement Linked Open Data [PDF]
, 2015 An increasing amount of public procurement data is nowadays being ported to linked data format, in view of its exploitation by government, commercial as well as non-profit subjects. One of the crucial tasks in public procurement is matchmaking demand with supply.
Mynarz, Jindřich +2 more
openaire +2 more sources