Results 31 to 40 of about 4,236,805 (394)

Trends in the Development of Antibody-Drug Conjugates for Cancer Therapy

Antibodies, 2023
In cancer treatment, the first-generation, cytotoxic drugs, though effective against cancer cells, also harmed healthy ones. The second-generation targeted cancer cells precisely to inhibit their growth.
Chi Hun Song, Minchan Jeong, Hyukmin In, Ji Hoe Kim, Chih-Wei Lin, Kyung Ho Han   +5 more
doaj   +1 more source

Vapor-phase linker exchange of metal-organic frameworks

Science Advances, 2020
A solvent-free strategy of vapor-phase linker exchange is developed for postsynthetic modification of metal-organic frameworks. Metal-organic frameworks (MOFs) have been attracting intensive attention because of their commendable potential in many ...
Wufeng Wu, Jingyi Su, Miaomiao Jia, Zhanjun Li, Guoqiang Liu, Wanbin Li   +5 more
semanticscholar   +1 more source

Microwave (MW), Ultrasound (US) and Combined Synergic MW-US Strategies for Rapid Functionalization of Pharmaceutical Use Phenols

Molecules, 2018
Increasingly stringent regulations aimed at protection of the natural environment have stimulated the search for new synthetic methodologies in organic and medicinal chemistry having no or minimum harmful effect.
Anna Pawełczyk, Katarzyna Sowa-Kasprzak, Dorota Olender, Lucjusz Zaprutko   +3 more
doaj   +1 more source

ENERGY TRANSFER IN TRIMERIC C-PHYCOCYANIN STUDIED BY PICOSECOND FLUORESCENCE KINETICS [PDF]

, 1986
The excited state kinetics of trimeric C-phycocyanin from Mastigocladus laminosus has been measured as a function of the emission and excitation wavelength by the single-photon timing technique with picosecond resolution and simultaneous data analysis. A
Holzwarth, A. R., John, Wolfhart, Scheer, Hugo, Wendler, J.   +3 more
core   +1 more source

iFLinkC: an iterative functional linker cloning strategy for the combinatorial assembly and recombination of linker peptides with functional domains

Nucleic Acids Research, 2020
Recent years have witnessed increasing efforts to engineer artificial biological functions through recombination of modular-organized toolboxes of protein scaffolds and parts.
Alexander Gräwe, Jan Ranglack, A. Weyrich, V. Stein   +3 more
semanticscholar   +1 more source

Acid-Labile Traceless Click Linker for Protein Transduction [PDF]

, 2012
Intracellular delivery of active proteins presents an interesting approach in research and therapy. We created a protein transduction shuttle based on a new traceless click linker that combines the advantages of click reactions with implementation of ...
Bachelder E. M., Dohmen C., Engin K., Ernst Wagner, Frohlich T., Kevin Maier, Lee Y., Meyer M., Meyer M., Meyer M., Miyata K., Murphy R. F., Murthy N., Nieto M. A., Rozema D. B., Rozema D. B., Saxon E., Schaffert D., Vallee M. R., Wagner E., Wagner E., Yu H.   +21 more
core   +1 more source

Linker-mediated self-assembly of mobile DNA-coated colloids

, 2020
Developing construction methods of materials tailored for given applications with absolute control over building block placement poses an immense challenge.
Ciamarra, Massimo Pica, Hu, Hao, Ni, Ran, Xia, Xiuyang   +3 more
core   +1 more source

Temperature-sensitive protein–DNA dimerizers [PDF]

, 2005
Programmable DNA-binding polyamides coupled to short peptides have led to the creation of synthetic artificial transcription factors. A hairpin polyamide-YPWM tetrapeptide conjugate facilitates the binding of a natural transcription factor Exd to an ...
Ansari, Aseem Z., Arndt, Hans-Dieter, Dervan, Peter B., Hauschild, Karl E., Metzler, Renee E., Moretti, Rocco, Raffaelle, Marni   +6 more
core   +1 more source

Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability. [PDF]

, 2019
HIV-1 Rev is an essential viral regulatory protein that facilitates the nuclear export of intron-containing viral mRNAs. It is organized into structured, functionally well-characterized motifs joined by less understood linker regions.
Fernandes, Jason D, Frankel, Alan D, Jayaraman, Bhargavi, Smith, Cynthia, Yang, Shumin   +4 more
core   +3 more sources

Antibody-drug conjugates: recent advances in conjugation and linker chemistries

Protein & Cell, 2016
The antibody-drug conjugate (ADC), a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules (payloads) through chemical linkers, is a novel therapeutic format and has great potential to make a paradigm shift in cancer ...
K. Tsuchikama, Z. An
semanticscholar   +1 more source