Results 51 to 60 of about 4,098,264 (291)

Thiol-Reactive PODS-Bearing Bifunctional Chelators for the Development of EGFR-Targeting [¹⁸F]AlF-Affibody Conjugates

Molecules, 2020
Site-selective bioconjugation of cysteine-containing peptides and proteins is currently achieved via a maleimide–thiol reaction (Michael addition).
Chiara Da Pieve, Ata Makarem, Stephen Turnock, Justyna Maczynska, Graham Smith, Gabriela Kramer-Marek   +5 more
doaj   +1 more source

Quantitative prediction of multivalent ligand–receptor binding affinities for influenza, cholera, and anthrax inhibition [PDF]

, 2018
Multivalency achieves strong, yet reversible binding by the simultaneous formation of multiple weak bonds. It is a key interaction principle in biology and promising for the synthesis of high-affinity inhibitors of pathogens. We present a molecular model
Liese, Susanne, Netz, Roland R.
core   +2 more sources

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]

, 2014
Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Goulet, Adeline, Grossmann, S.P., Jung, Y., Major, J., Moores, Carolyn A., Rosenfeld, S.S.   +5 more
core   +2 more sources

Redox-active ferrocene-modified Cowpea mosaic virus nanoparticles [PDF]

, 2010
A naturally occurring nanoparticle, the plant virus Cowpea mosaic virus, can be decorated with ferrocene derivatives, of various linker lengths with amine and carboxylategroups, on the external surface using a range of conjugation strategies.
Alaa A. A. Aljabali, Astruc, Beasley, Chatterji, Chidsey, Constable, David J. Evans, Evans, Evans, Frederix, George P. Lomonossoff, Green, J. Elaine Barclay, Julea N. Butt, Lin, Lomonossoff, Lopez, Molina, Newkome, Padeste, Steinmetz, Steinmetz, Steinmetz, Togni, Wang, Wang, Wellink, Yang, Yang   +28 more
core   +1 more source

A New Link for a Linker Histone [PDF]

Molecular Cell, 2003
Classically, the functions of linker histones (histones H1 and variants) have been related mainly to chromatin organization and the ensuing consequences on transcription. Remarkably, yeast histone H1 may not comply, as it appears to regulate homologous recombination specifically.
Raymund J. Wellinger, Antonio Conconi
openaire   +3 more sources

Effects of antibody, drug and linker on the preclinical and clinical toxicities of antibody-drug conjugates

mAbs, 2016
Antibody-drug conjugates (ADCs) represent a new class of cancer therapeutics. Their design involves a tumor-specific antibody, a linker and a cytotoxic payload.
H. Donaghy
semanticscholar   +1 more source

The control technology of harmful substances impacting the quality of peanut oil: A review

Grain & Oil Science and Technology
Peanut is a globally important leguminous crop and one of the most important oil crops. In response to the growing demand for high-quality peanut oil, advancements in processing technologies have led to significant improvements in oil quality.
Zifu Ni, Xiao Ouyang, Azhen Nie, Lina Huang, Ruoqi Li, Jinling Li, Peng Chen   +6 more
doaj   +1 more source

Discovery of potent histone deacetylase inhibitors with modified phenanthridine caps

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
In discovery of novel HDAC inhibitory with anticancer potency, pharmacophores of phenanthridine were introduced to the structure of HDAC inhibitors. Fatty and aromatic linkers were evaluated for their solubility and activity.
Wenli Fan, Lin Zhang, Xuejiang Wang, Haiyong Jia, Lei Zhang   +4 more
doaj   +1 more source

Methods for treating bone deficit conditions with benzothiazole [PDF]

, 1999
" Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or ""linker"" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in ...
Baindur, Nand, Hurley, Laurence H., Kerwin, Sean M., Mundy, Gregory R., Orme, Mark W., Petrie, Charles R. III, Robbins, Kirk G.   +6 more
core   +1 more source

Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy

Molecules, 2017
Antibody-drug conjugates (ADCs) are a class of highly potent biopharmaceutical drugs generated by conjugating cytotoxic drugs with specific monoclonal antibodies through appropriate linkers.
Hao Chen, Zongtao Lin, Kinsie E. Arnst, Duane D. Miller, Wei Li   +4 more
doaj   +1 more source