Results 71 to 80 of about 4,098,264 (291)
Internally and externally headed relative clauses in Tagalog
Glossa, 2017 Head nominals in Tagalog relative clauses can surface in three distinct positions: preceding the clause, immediately following the embedded verb, and in argument position within the clause. This paper accounts for these possibilities by positing that the
Edith Aldridge
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Indian Journal of Medical and Paediatric Oncology, 2020 Antibody drug conjugates (ADCs) are chemically engineered drugs consisting of monoclonal antibody (mAb) and cytotoxic compound attached chemically by a linker. Upon attachment to a specific target antigen, ADC enters into the cell and payload is released,
Stalin Bala, Siva K Prasad
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The Construction of Immunoliposomes (Review)
Разработка и регистрация лекарственных средств, 2022 Introduction. Due to the discovery of antibodies (Ab) targeting molecule with high specificity to the ligand, the "magic bullet" concept has been successfully implemented with various immunoconjugated drugs. Since 1980, Ab conjugates with liposomes, i.e.,
M. V. Dmitrieva +4 more
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Allosteric linkers in cAMP signalling [PDF]
Biochemical Society Transactions, 2014 Weak interactions mediated by dynamic linkers are key determinants of allosteric regulation in multidomain signalling proteins. However, the mechanisms of linker-dependent control have remained largely elusive. In the present article, we review an allosteric model introduced recently to explain how signalling proteins effectively sense and respond to ...
Bryan VanSchouwen +7 more
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Pharmaceuticals, 2021 Combining the selective targeting of tumor cells through antigen-directed recognition and potent cell-killing by cytotoxic payloads, antibody-drug conjugates (ADCs) have emerged in recent years as an efficient therapeutic approach for the treatment of ...
Vesela Kostova +3 more
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Molecular Cell, 2003 Molecular motors are the long-haul carriers of eukaryotic cells, moving cargos bidirectionally along microtubule tracks. In the December 12th issue of Cell, report that HDAC6, a tubulin deacetylase, functions as an adaptor that links cargos of aggregated protein to the minus end-directed motor, cytoplasmic dynein.
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Linkers of secondary structures in proteins [PDF]
Protein Science, 1997 AbstractLinkers that connect repeating secondary structures fall into conformational classes based on distance and main‐chain torsion clustering. A data set of 300 unique protein chains with low pairwise sequence identity was clustered into only a few groups representing the preferred motifs.
P. J. Munson, V. Geetha
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Tuning the Cross-Linker Crystallinity of a Stretchable Polymer Semiconductor
Chemistry of Materials, 2018 The cross-linking of conjugated polymers has been demonstrated to be an effective strategy to improve its elastic properties to give deformable semiconductors for plastic electronics. While there have been extensive studies of the structural requirements
G. Wang +8 more
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Exploration of the antibody–drug conjugate clinical landscape
mAbs, 2023 The antibody–drug conjugate (ADC) field has undergone a renaissance, with substantial recent developmental investment and subsequent drug approvals over the past 6 years. In November 2022, ElahereTM became the latest ADC to be approved by the US Food and
Heather Maecker +4 more
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ATP-dependent chromatosome remodeling [PDF]
, 2008 Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Dimitrov S. +6 more
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