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Biocatalysis of linoleic acid to conjugated linoleic acid

Lipids, 2006
AbstractCLA refers to a group of geometrical and positional isomers of linoleic acid (LA) with conjugated double bonds. CLA has been reported to have diverse health benefits and biological properties. Traditional organic synthesis is highly capital‐intensive and results in an isomeric mixture of CLA isomers.
Sibel, Irmak   +4 more
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Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids

Organic Letters, 2019
The syntheses of linoleic acid esters of hydroxy linoleic acids (LAHLAs) present in oat oil and human serum have been achieved, providing access to material for testing and the determination of the stereochemistry of the natural compounds. While 9- and 13-LAHLAs were found to be a mixture of enantiomers 15-LAHLA is generated in a single optical form in
Huijing Wang   +7 more
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Linoleic Acid Supplementation

Pediatrics, 1980
The study of Chase et al1 was designed to determine whether linoleic acid supplementation would lead to a greater improvement in the growth and clinical status of children with cystic fibrosis than would be expected to result from an increased energy intake alone. There are two points that we would like to make regarding this study.
H G, Parsons, P B, Pencharz
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Conjugated linoleic acid

American Journal of Health-System Pharmacy, 2006
The term conjugated linoleic acid (CLA) describes a group of conjugated, octadecadieonic acid isomers of linoleic acid.[1][1] The two isomers with known biological activity are cis -9, trans -11 linoleic acid and trans -10, cis -12 linoleic acid.
Elizabeth, Poole, Cydney E, McQueen
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Conjugated Linoleic Acids

Current Sports Medicine Reports, 2008
Conjugated linoleic acid (CLA) has been studied extensively in both animal and human models. CLA supplementation has been attributed to provide several health benefits that are based largely upon animal and in vitro studies. Recent literature suggests that CLA supplementation possesses an anti-adipogenic role.
Bill, Campbell, Richard B, Kreider
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The reaction of mercaptoacetic acid with methyl linoleate and linoleic acid

Journal of the American Oil Chemists' Society, 1958
SummaryThe reaction of mercaptoacetic acid with methyl linoleate and with linoleic acid was investigated. The reaction proceeded at low and erratic rates, with and without catalysts, such as peroxides at various temperatures, but could be accelerated by use of a large excess of mercaptoacetic acid.Addition of 1 mole of mercaptoacetic acid to 1 mole of ...
Sara P. Fore   +2 more
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Autoxidation of Linoleic Acid

Nature, 1945
IN connexion with work on the purification of soybean lipoxidase1, an investigation was undertaken to identify the primary products formed from linoleic acid when it was oxidized by molecular oxygen with this enzyme or with inorganic catalysts.
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Bioconversion of Linoleic Acid into Conjugated Linoleic Acid by Immobilized Lactobacillus reuteri

Biotechnology Progress, 2003
Lactobacillus reuteri was immobilized on silica gel to evaluate the bioconversion of linoleic acid (LA) into conjugated linoleic acid (CLA), consisting of cis-9,trans-11 and trans-10,cis-12 isomers. The amount of cell to carrier, the reaction time, and the substrate concentration, pH, and temperature for CLA production were optimized at 10 mg of cells/(
Sun-Ok, Lee   +2 more
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Kinetics of microbial hydrogenation of free linoleic acid to conjugated linoleic acids

Journal of Applied Microbiology, 2008
To investigate the ability of selected probiotic bacterial strains to produce conjugated linoleic acid (CLA) and also to estimate the biohydrogenation kinetics of Lactobacillus acidophilus on the production of CLA from free linoleic acid (LA).Six probiotic bacteria, Lact. paracasei, Lact. rhamnosus GG, Lact.
H, Xu   +5 more
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Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis

Nutrition and Cancer, 1997
Previous work by Ip and co-workers showed that mammary cancer prevention by conjugated linoleic acid (CLA) is independent of the level of fat in the diet. Because CLA is an isomer of linoleic acid, there is the question regarding whether the effect of CLA is due to a displacement of linoleic acid in cells.
C, Ip, J A, Scimeca
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