Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
A higher serum lipase cut-off improves the diagnosis of acute pancreatitis in patients with non-epigastric abdominal pain. [PDF]
iScienceJahangir S +10 more
europepmc +1 more source
When Enzymes Mislead: Assessing the Value of MRCP in Suspected Choledocholithiasis
ANZ Journal of Surgery, EarlyView.ABSTRACT Background The diagnosis of choledocholithiasis (CDL) requires balancing timely intervention against the risks of unnecessary invasive procedures. Although liver function tests (LFTs) are widely used for risk stratification, their static values and short‐term trends remain poorly defined in predicting persistent common bile duct stones.
Renato Pitesa +4 more
wiley +1 more source
Genomic Insights into Lipid Dependency in Atypical Strains of Malassezia pachydermatis. [PDF]
MycopathologiaDíaz L +4 more
europepmc +1 more source
Immune‐related adverse events in the treatment of Hodgkin lymphoma with immune checkpoint inhibitors
British Journal of Haematology, EarlyView.Summary Immune checkpoint inhibitors (ICIs) have shown to be effective in the treatment of Hodgkin lymphoma (HL). ICI treatment is associated with the occurrence of a series of immune‐related adverse events (irAEs). We conducted an ambispective observational study on 96 patients with relapsed/refractory HL treated with ICIs to determine the incidence ...
Lisa Argnani +9 more
wiley +1 more source
Amyloid‐β aggregates induce vasculopathy via ferroptosis in brain endothelial cells
Brain Pathology, EarlyView.Blood–brain barrier (BBB) disruption is evident in brains with amyloidopathy. In this study, we demonstrate that amyloid β (Aβ) drives abnormal lipid metabolism and lipid droplet formation in brain endothelial cells, leading to lipid peroxidation and ferroptosis.
Suhyeon Son +7 more
wiley +1 more source
Safety evaluation of the food enzyme triacylglycerol lipase from the genetically modified <i>Trichoderma reseei</i> strain AR-822. [PDF]
EFSA JEFSA Panel on Food Enzymes (FEZ) +17 more
europepmc +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes
British Journal of Pharmacology, EarlyView.Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier +9 more
wiley +1 more source
The utilization of oral feeding in pediatric pancreatitis: a randomized controlled study. [PDF]
J Pediatr (Rio J)Han Y +8 more
europepmc +1 more source