Results 281 to 290 of about 257,238 (346)

Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis

Med Research, EarlyView.
The review identifies glucocorticoid‐induced osteocyte/osteoblast apoptosis as central to femoral head osteonecrosis (GION), mediated through STAT1‐caspase‐3, PI3K/Akt, Wnt/β‐catenin, and oxidative stress pathways. Emerging therapies targeting these pathways (e.g., HIF‐1α stabilization, AMPK activation, and exosome‐mediated miRNA delivery) show ...
Xiumei Tang, Yanyun Pang, Peijia Zhu, Zhengdong Zhang, Sen Guo, Zhijian Wei, Wenzhao Wang, Bin Ning   +7 more
wiley   +1 more source

Engineering an antimicrobial chimeric endolysin that targets the phytopathogen Pseudomonas syringae pv. actinidiae. [PDF]

J Biol Chem
Warring SL, Sisson HM, Randall G, Grimon D, Dams D, Gutiérrez D, Fellner M, Fagerlund RD, Briers Y, Jackson SA, Fineran PC.   +10 more
europepmc   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Pancreatic Panniculitis Without Pancreatopathy: A Rare Complication of Splenic Vein Stenting for Portal Hypertension in Myeloproliferative Syndrome. [PDF]

United European Gastroenterol J
Butnaru E, Tran Van S, Brazier F, Yzet C.   +3 more
europepmc   +1 more source

The Dual Role of Exosomes in the Tumor Microenvironment: From Pro‐Tumorigenic Signaling to Immune Modulation

Med Research, EarlyView.
Tumor‐derived exosomes influence proliferation, invasion, angiogenesis, metabolic adaptation, and resistance to therapy. They also shape the immune landscape by modulating antigen presentation, suppressing cytotoxic lymphocyte activity, and promoting the expansion of immunosuppressive cell populations. Although frequently associated with immune evasion,
Jiale Li, Jun Peng, Jiachong Wang, Zigui Chen   +3 more
wiley   +1 more source

Ionic organic cage as a versatile platform for immobilizing chemical and enzymatic sites for chemoenzymatic catalysis. [PDF]

Nat Commun
Zhao K, Tan LX, Gao N, Sun JK.
europepmc   +1 more source

The Potential Ability of Betulinic Acid to Prevent Experimentally Induced Acute Pancreatitis in Rats. [PDF]

Basic Clin Pharmacol Toxicol
Yenice G, Ozkanlar S, Bolat I, Yildirim S.   +3 more
europepmc   +1 more source

Clinical Evaluation of Patients with Elevated Serum Lipase. [PDF]

Dig Dis Sci
Chatterjee A, Prado R, Siddiki H, Stevens T.   +3 more
europepmc   +1 more source

Therapeutic Potential of <i>Plantago ovata</i> Bioactive Extracts Obtained by Supercritical Fluid Extraction as Influenced by Temperature on Anti-Obesity, Anticancer, and Antimicrobial Activities. [PDF]

Plants (Basel)
Qanash H, Bazaid AS, Binsaleh NK, Alshammari AS, Eltayeb R.   +4 more
europepmc   +1 more source

Recurrent Self‐Limiting Acute Pancreatitis: Intraductal Papillary Mucinous Neoplasm Requiring Surgery

The Kaohsiung Journal of Medical Sciences, EarlyView.
Chia‐Hsin Chang, Yu‐Chun Ma, Shih‐Chang Chuang, Chih‐Wen Wang   +3 more
wiley   +1 more source