Results 81 to 90 of about 251,658 (355)

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
wiley   +1 more source

Anchor Peptide‐Based Immobilization Strategy Promote the Applications of Pickering Emulsion System in Natural Products Glycosylation

Angewandte Chemie, EarlyView.
This study designs an anchor peptide‐based immobilization strategy to expand the application of Pickering emulsion to glycosyltransferases (GTs) for the first time, addressing low conversion challenge in aqueous solutions. The glycosylation Pickering emulsion achieved more than 90% conversion of natural product glycosides with high recyclability ...
Peng Zhang, Zhe Dong, Shuaiqi Meng, Zhongyu Li, Yu Ji, Ulrich Schwaneberg   +5 more
wiley   +2 more sources

Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis

Advanced Science, EarlyView.
This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Xiaoyun Cao, Yang Hu, Kai Yan Cheng, Hui Li, Yang Ji, Yan Liu, Matthew Ackers‐Johnson, Roger S.Y. Foo, Yujia Shen, Haojie Yu   +13 more
wiley   +1 more source

Supramolecular Gels as Active Tools for Reaction Engineering

Angewandte Chemie, EarlyView.
The unique combination of environments within gels, self‐assembled from low‐molecular‐weight gelators, offers the ability to control reactivity in new ways, achieving unique reaction outcomes, leading to the emerging concept of supramolecular gels as nanoreactors. Smart chemical engineering methods enable the use of such gels to fabricate materials and
David K. Smith
wiley   +2 more sources

Medicinal Plants and Their Inhibitory Activities against Pancreatic Lipase: A Review

Evidence-Based Complementary and Alternative Medicine, 2015
Obesity is recognized as a major life style disorder especially in developing countries and it is prevailing at an alarming speed in new world countries due to fast food intake, industrialization, and reduction of physical activity.
A. Seyedan, M. Alshawsh, M. Alshagga, Sanaz Koosha, Z. Mohamed   +4 more
semanticscholar   +1 more source

Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects

Advanced Science, EarlyView.
Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian, Shujiang Sun, Xinran Qiu, Junrui Wang, Yuanyuan Gao, Jianmei Chen, Xiang Han, Zhengyang Bao, Xiaohan Guo, Yuqi Sun, Yuxin Lin, Mengru Hu, Feng Zhang, Zili Zhang, Feixia Wang, Shizhong Zheng, Jiangjuan Shao   +16 more
wiley   +1 more source

Imaging Heterogeneous Patterns of Aminopeptidase N Activity in Hierarchical Tissue Structures Through High‐Resolution Whole‐Organ 3D Mapping

Angewandte Chemie, EarlyView.
Enzymes regulate physiological functions, and their abnormal activity is associated with diseases. Here, we present a method for high‐resolution 3D mapping of enzyme activity using tissue clearing and an activity‐based covalent probe. Focusing on aminopeptidase N, we developed ANA‐o‐BODIPY, which records enzyme activity via covalent labeling.
Bo Yi, Hiroyuki Yatabe, Daichi M. Sakamoto, Iori Tamura, Yutaro Saito, Naoki Yamada, Ruki Ashikaga, Masafumi Kuroda, Shimpei I. Kubota, Kazuki Tainaka, Shinsuke Sando   +10 more
wiley   +2 more sources

Significant elevations of serum lipase not caused by pancreatitis: a systematic review.

HPB, 2015
BACKGROUND Many authors advocate lipase as the preferred serological test for the diagnosis of pancreatitis and a cut-off level of three or more times the upper limit of normal (ULN) is often quoted.
Ahmer M Hameed, V. Lam, H. Pleass
semanticscholar   +1 more source

Hydrogel‐Transformable Probiotic Powder for Targeted Eradication of Helicobacter pylori with Enhanced Gastric Mucosal Repair and Microbiota Preservation

Advanced Science, EarlyView.
A multifunctional, edible, and hydrogel‐transformable probiotic powder is developed based on the “bacteria‐mediated bacterial eradication” strategy. By leveraging the targeted binding capability of L. reuteri to H. pylori, this approach achieves an integrated therapeutic effect, including bactericidality, anti‐inflammation, gastric mucosal repair, and ...
Yongkang Lai, Hanchun Shen, Shige Wang, Yongliang Ouyang, Xinyuan Zhang, Bin Hu, Xiaoyi Zhang, Guisheng Li, Lizhi Xu, Jiulong Zhao   +9 more
wiley   +1 more source

Robust Controlled Degradation of Enzyme Loaded PCL‐Based Fibrous Scaffolds Toward Scarless Skin Tissue Regeneration

Advanced Science, EarlyView.
A novel biodegradable wound dressing (E‐PCLs) based on polycaprolactone (PCL) and an enzyme complex (RHP‐BCL) is developed using a fiber microfluidic electrospinning technique. The dressing achieves complete degradation within 14 days, eliminates microplastic residues, and promotes scar‐free healing (99% in 21 days).
Lingling Fan, Weiliang Dong, Jianqi Lu, Yujia Peng, Bin Xie, Ping Wei, Min Jiang, Su Chen   +7 more
wiley   +1 more source