Results 241 to 250 of about 23,163,981 (284)

Nucleoside–Lipid-Based Nanoparticles for Cisplatin Delivery

ACS Nano, 2011
The use of delivery vehicles to selectively transport anticancer agents to tumors is very attractive to address both toxicity and efficacy issues. We report a novel approach based on hybrid nucleoside-lipids allowing the efficient encapsulation and delivery of cisplatin.
Khiati, S., Luvino, D., Oumzil, K., Chauffert, B., Camplo, M., Barthelemy, P.   +5 more
openaire   +3 more sources

Lipid-based nanoparticle technologies for liver targeting

Advanced Drug Delivery Reviews, 2020
Liver diseases such as hepatitis, cirrhosis, and hepatocellular carcinoma are global health problems accounting for approximately 800 million cases and over 2 million deaths per year worldwide. Major drawbacks of standard pharmacological therapies are the inability to deliver a sufficient concentration of a therapeutic agent to the diseased liver, and ...
Roland, Böttger, Griffin, Pauli, Po-Han, Chao, Nojoud, Al Fayez, Lukas, Hohenwarter, Shyh-Dar, Li   +5 more
openaire   +2 more sources

Cancer theranostic applications of lipid-based nanoparticles

Drug Discovery Today, 2018
A variety of nanoplatforms have been developed and applied for cancer therapy, imaging, or the combination thereof. These nanoplatforms, combined with therapeutic and imaging functionalities, display great potential to enhance medical care. In particular, lipid-based nanoparticles (LNPs) are among the most-studied platforms that have resulted in many ...
Wei-Lun, Tang, Wei-Hsin, Tang, Shyh-Dar, Li   +2 more
openaire   +2 more sources

Lipid-Based Nanoparticles in The Systemic Delivery of siRNA

Nanomedicine, 2013
RNAi therapeutics are believed to be the future of personalized medicine and have shown promise in early clinical trials. However, many physiological barriers exist in the systemic delivery of siRNAs to the cytoplasm of targeted cells to perform their function. To overcome these barriers, many siRNA delivery systems have been developed.
Qiaoya, Lin, Juan, Chen, Zhihong, Zhang, Gang, Zheng   +3 more
openaire   +2 more sources

Progress in Lipid-Based Nanoparticles for Cancer Therapy

Critical Reviews in Oncogenesis, 2014
Most conventional cancer therapeutics gain limited access to many types of tumors while having considerable adverse effects, resulting in low therapeutic efficacy and high toxicity. Therefore, research has now focused on the development of novel drug delivery systems (DDS) with the goal of maintaining high therapeutic drug levels at malignant cells and
Sarina, Grinberg, Charles, Linder, Eliahu, Heldman   +2 more
openaire   +2 more sources

Lipid-based nanoparticles in the treatment of erectile dysfunction

International Journal of Impotence Research, 2020
Erectile dysfunction (ED) is a common disorder among men, with significant public health implications. Current therapies have certain limitations including efficacy and safety issues, necessitating the development of novel therapeutic strategies for ED.
openaire   +3 more sources

In Vivo Delivery of RNAi with Lipid-Based Nanoparticles

Annual Review of Biomedical Engineering, 2011
RNA interference (RNAi) technology represents a fundamentally new category of treatments for human disease by addressing targets that are traditionally considered undruggable with existing medicines. The major challenge for RNAi-based therapy is the delivery system that meets human therapeutic needs.
Leaf, Huang, Yang, Liu
openaire   +2 more sources

Lipid-based Nanoparticles for Nucleic Acid Delivery

Pharmaceutical Research, 2007
Lipid-based colloidal particles have been extensively studied as systemic gene delivery carriers. The topic that we would like to emphasize is the formulation/assembly of lipid-based nanoparticles (NP) with diameter under 100 nm for delivering nucleic acid in vivo.
Weijun, Li, Francis C, Szoka
openaire   +2 more sources

Altering the immune response with lipid-based nanoparticles

Journal of Controlled Release, 2012
Lipid-based nanoparticles (LNPs) hold great promise as delivery vectors in the treatment of cancer, inflammation, and infections and are already used in clinical practice. Numerous strategies based on LNPs are being developed to carry drugs into specific target sites.
Dalit, Landesman-Milo, Dan, Peer
openaire   +2 more sources

Lipid-Based Nanoparticles for RNA Delivery

Various nanoparticle-based delivery systems have been developed for the encapsulation and protection of active cargoes. Lipid nanoparticles represent one of the most widely used nanoparticle-based delivery systems for in vitro and in vivo applications, especially for the delivery of ribonucleic acid (RNA).
Xiomara, Calderón-Colón, Richard, Egan
openaire   +2 more sources