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Drug loading to lipid-based cationic nanoparticles
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2005Abstract Lipid-based cationic nanoparticles are a new promising option for tumor therapy, because they display enhanced binding and uptake at the neo-angiogenic endothelial cells, which a tumor needs for its nutrition and growth. By loading suitable cytotoxic compounds to the cationic carrier, the tumor endothelial and consequently also the tumor ...
Leide P. Cavalcanti +3 more
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Lipid-based nanoparticles for drug delivery
Lipid-based nanoparticles represent a promising strategy for the delivery of therapeutics, offering potential treatment avenues for various diseases. The thesis aimed to explore two examples of lipid-based nanoparticle systems, focusing on their efficacy, safety, and stability to evaluate their suitability for future clinical use.Mahmoud, Mahmoud Sayed Hanafy +1 more
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Clickable lipid-based nanoparticles for targeted theranostics
2018This thesis was undertaken to develop a novel drug carrier for diseases such as cancer which would exhibit better localised and controlled release of contents to improve treatment efficacy and reduce side effects. This involved using lipid-based nanotechnology and bioorthogonal chemistry together in an attempt to specifically target the tumor cells.
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Microfluidic assembly of lipid-based oligonucleotide nanoparticles.
Anticancer research, 2011Oligonucleotides (ONs) have shown great promise as therapeutic agents for various diseases. It is necessary to provide a protocol for preparation of ON-loaded lipid nanoparticles (LNPs) in a reproducible manner on a laboratory scale.A 3-inlet microfluidic (MF) chip-based device was used to synthesize LNPs at the lipid/ON ratio of 10/1 (w/w) and at flow
Bo, Yu +6 more
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Lipid-based nanoparticles for nucleic acids delivery
Physical Sciences ReviewsAbstract This chapter highlights challenges and advancements in the production of lipid-based nanoparticles (LNPs) and their application in nucleic acid-based therapies. Recently, mRNA-based vaccines for COVID-19 immunization revealed that the use of nucleic acids is a promising strategy to develop treatments at high therapeutic ...
Sarnelli S. +3 more
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Lipid-based nanoparticles in photodynamic therapy
2023Camila Fabiano de Freitas +2 more
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Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects
Nature Reviews Clinical Oncology, 2023Edo Kon, Nitay Ad-El, Dan Peer
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