Results 251 to 260 of about 186,102 (296)
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Nucleoside–Lipid-Based Nanoparticles for Cisplatin Delivery
ACS Nano, 2011The use of delivery vehicles to selectively transport anticancer agents to tumors is very attractive to address both toxicity and efficacy issues. We report a novel approach based on hybrid nucleoside-lipids allowing the efficient encapsulation and delivery of cisplatin.
Khiati, S. +5 more
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In vivo fate of lipid-based nanoparticles
Drug Discovery Today, 2017The in vivo fate of lipid-based nanoparticles (LBNs) is essentially determined by the properties of their lipid compositions. LBNs are rapidly degraded via lipolysis wherever lipases are abundant, especially in the gastrointestinal tract. LBNs that survive lipolysis can be translocated through the circulation to reach terminal organs or tissues.
Jianping, Qi +5 more
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Cancer theranostic applications of lipid-based nanoparticles
Drug Discovery Today, 2018A variety of nanoplatforms have been developed and applied for cancer therapy, imaging, or the combination thereof. These nanoplatforms, combined with therapeutic and imaging functionalities, display great potential to enhance medical care. In particular, lipid-based nanoparticles (LNPs) are among the most-studied platforms that have resulted in many ...
Wei-Lun, Tang +2 more
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Lipid-based Nanoparticles for Nucleic Acid Delivery
Pharmaceutical Research, 2007Lipid-based colloidal particles have been extensively studied as systemic gene delivery carriers. The topic that we would like to emphasize is the formulation/assembly of lipid-based nanoparticles (NP) with diameter under 100 nm for delivering nucleic acid in vivo.
Weijun, Li, Francis C, Szoka
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Progress in Lipid-Based Nanoparticles for Cancer Therapy
Critical Reviews in Oncogenesis, 2014Most conventional cancer therapeutics gain limited access to many types of tumors while having considerable adverse effects, resulting in low therapeutic efficacy and high toxicity. Therefore, research has now focused on the development of novel drug delivery systems (DDS) with the goal of maintaining high therapeutic drug levels at malignant cells and
Sarina, Grinberg +2 more
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Lipid-Based Nanoparticles: SLN, NLC, and MAD
2019Lipid-based nanosystems have been widely proposed as novel drug carrier systems since they have gained interest as matrixes able to dissolve and to control the delivery of active molecules, on one hand improving their solubility in water and their bioavailability and on the other reducing side-effects.
R. Cortesi +3 more
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Lipid-Based Nanoparticles for RNA Delivery
Various nanoparticle-based delivery systems have been developed for the encapsulation and protection of active cargoes. Lipid nanoparticles represent one of the most widely used nanoparticle-based delivery systems for in vitro and in vivo applications, especially for the delivery of ribonucleic acid (RNA).Xiomara, Calderón-Colón, Richard, Egan
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Altering the immune response with lipid-based nanoparticles
Journal of Controlled Release, 2012Lipid-based nanoparticles (LNPs) hold great promise as delivery vectors in the treatment of cancer, inflammation, and infections and are already used in clinical practice. Numerous strategies based on LNPs are being developed to carry drugs into specific target sites.
Dalit, Landesman-Milo, Dan, Peer
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Lipid-Based Nanoparticles as Nonviral Gene Delivery Vectors
2013Efficient delivery of nucleic acids into cells is a promising technique to modulate cellular gene expression for therapeutic and research applications. Cationic lipid-based liposomes represent one of the most intensively studied and employed nonviral vectors.
D. Pezzoli +3 more
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Lipid-Based Nanoparticles for Vaccine Applications
2015Currently available vaccine adjuvants are ineffective against a wide range of infectious pathogens as well as cancers. Therefore, there is a critical demand for new vaccine strategies that can elicit potent cellular and humoral immune responses. Liposomes have been widely examined as vaccine delivery systems because of their safety, low toxicity, and ...
Rui Kuai +3 more
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