Results 221 to 230 of about 890,691 (262)

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

open access: yesAdvanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia   +13 more
wiley   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

open access: yesAdvanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai   +7 more
wiley   +1 more source

Gingival Verruciform Xanthoma: A Rare Case Report With Updated Insights Into Pathogenesis. [PDF]

open access: yesCase Rep Dent
Jeevarathan J   +6 more
europepmc   +1 more source

Early ApoA-I Treatment Prevents Postsurgical Atherosclerotic Plaque Destabilization. [PDF]

open access: yesCirc Res
Boucher DM   +5 more
europepmc   +1 more source

Spatial omics of neuroinflammation: insights across brain diseases. [PDF]

open access: yesFront Immunol
Li M   +6 more
europepmc   +1 more source

Stacked human aortic endothelial cells induce atherosclerotic fatty streaks and release proinflammatory cytokines and chemokines. [PDF]

open access: yesMechanobiol Med
Zeng Y   +11 more
europepmc   +1 more source

Lipid and Foam Cell Accumulation as Novel Pathological Features of Benign Prostatic Hyperplasia. [PDF]

open access: yesProstate
Julianingsih D   +9 more
europepmc   +1 more source

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