Results 1 to 10 of about 2,038,928 (302)

HILPDA Uncouples Lipid Droplet Accumulation in Adipose Tissue Macrophages from Inflammation and Metabolic Dysregulation [PDF]

Cell Reports, 2020
Summary: Obesity leads to a state of chronic, low-grade inflammation that features the accumulation of lipid-laden macrophages in adipose tissue. Here, we determined the role of macrophage lipid-droplet accumulation in the development of obesity-induced ...
Xanthe A.M.H. van Dierendonck, Montserrat A. de la Rosa Rodriguez, Anastasia Georgiadi, Frits Mattijssen, Wieneke Dijk, Michel van Weeghel, Rajat Singh, Jan Willem Borst, Rinke Stienstra, Sander Kersten   +9 more
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Tumour-driven lipid accumulation in oenocytes reflects systemic lipid alterations. [PDF]

PLoS Genetics
Cancer cachexia is a multifactorial syndrome characterized by systemic metabolic dysfunction, including liver steatosis. In this study, we examined the role of larval oenocytes - hepatocyte-like cells, in a Drosophila model of cancer cachexia.
Chang Liu, Sofya Golenkina, Natasha Fahey, Priya Kumar, Louise Y Cheng   +4 more
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Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration [PDF]

Neural Regeneration Research, 2023
Lipid peroxidation and iron accumulation are closely associated with neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, or neurodegeneration with brain iron accumulation disorders.
Irene Villalón-García, Suleva Povea-Cabello, Mónica Álvarez-Córdoba, Marta Talaverón-Rey, Juan M Suárez-Rivero, Alejandra Suárez-Carrillo, Manuel Munuera-Cabeza, Diana Reche-López, Paula Cilleros-Holgado, Rocío Piñero-Pérez, José A Sánchez-Alcázar   +10 more
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Oxysterol undersulfation promotes osteoarthritis by fueling chondrocyte lipid accumulation [PDF]

Nature Communications
Osteoarthritis (OA) is a common degenerative joint disease with no curative treatments and a poorly understood etiology. Here, we report that defective sulfation, a largely underexplored chemical modification of lipid metabolites, drives pathogenic lipid
Huanbo Wang, Bowei Ni, Yu Qian, Guangyu Ding, Ting He, Xinyu Zhang, Hailun Xu, Xue Hao, Yaqian Hu, Di Wang, Qiang Jie, Ying Li, Tianyang Jie, Zhong Alan Li, Zhuojing Luo, Houfeng Zheng, Liu Yang, Chao Zheng   +17 more
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Lutein Attenuates Lipid Accumulation in Association with TFEB Nuclear Translocation and Autophagy–Lysosomal Responses in a Cellular Model of Hepatic Steatosis [PDF]

Antioxidants
Lutein is a dietary xanthophyll carotenoid valued for its antioxidant properties that has been shown to benefit liver health and reduce hepatic lipid accumulation; however, this lipid-lowering effect cannot be fully attributed to its antioxidant activity,
Faride Saud, Daniel Cabrera, Catalina Valladares, Marjorie De la Fuente López, Rodrigo Maldonado-Agurto, Diego Irribarra-Tapia, Elisa Balboa   +6 more
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ACAD8-mediated valine catabolism inhibits mTOR signaling to suppress lipid accumulation and progression of clear cell renal cell carcinoma [PDF]

Translational Oncology
Background: Clear cell renal cell carcinoma (ccRCC) poses a serious threat to human health. Abnormal lipid accumulation is a hallmark biological feature of this malignancy; however, its underlying mechanisms remain incompletely understood.
Runkun Fan, Zirui Dong, Weisong Wu, Yujie Jia, Hourui Tan, Qi Wang, Xiaoping Zhang   +6 more
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Swertia mussotii prevents high-fat diet-induced non-alcoholic fatty liver disease in rats by inhibiting expression the TLR4/MyD88 and the phosphorylation of NF-κB

Pharmaceutical Biology, 2022
Context Swertia mussotii Franch. (Gentianaceae) is a source of the traditional Tibetan medicine, ZangYinChen, and is used to treat chronic hepatitis and many types of jaundice.Objective This study explored the therapeutic effects and mechanism of S ...
Ming Dong Si, Meng Wu, Xi Zhen Cheng, Zhi Hong Ma, Yu Guang Zheng, Jing Li, Si Li, Yong Xing Song, Donglai Ma   +8 more
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ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway

Biology Direct, 2023
Background Ligamentum flavum (LF) hypertrophy is the main cause of lumbar spinal canal stenosis (LSCS). Previous studies have shown that LF hypertrophy tissue exhibits abnormal lipid accumulation, but the regulatory mechanism remains unclear.
Yanlin Cao, Jianjun Li, Sujun Qiu, Songjia Ni, Yang Duan   +4 more
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Puerarin Prevents Bisphenol S Induced Lipid Accumulation by Reducing Liver Lipid Synthesis and Promoting Lipid Metabolism in C57BL/6J Mice

Toxics, 2023
Bisphenol S (BPS) is an environmental pollutant that can accumulate in the human body and cause harm. Puerarin (PUE) is a flavonoid with anti-inflammatory and antioxidant effects.
Zi-Yao Wu, Li Luo, Ya-Qi Kan, Mei-Lin Qin, Hai-Ting Li, Qing-Zhi He, Huai-Cai Zeng   +6 more
doaj   +1 more source

Selenium reduces hepatopancreas lipid accumulation of grass carp (Ctenopharyngodon idella) fed high-fat diet via lipophagy activation

Animal Nutrition, 2023
It has been reported that selenium (Se) can reduce hepatopancreas lipid accumulation induced by high-fat diet. However, its mechanism is still unknown.
Xiaotian Zhang, Haibo Yu, Xianfang Yan, Pengju Li, Chi Wang, Cheng Zhang, Hong Ji   +6 more
doaj   +1 more source