Results 11 to 20 of about 3,316,815 (349)
Lipid Accumulation and Chronic Kidney Disease [PDF]
Nutrients, 2019 Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic kidney disease (CKD), suggesting that lipid accumulation in the renal parenchyma is detrimental to renal function.
Z. Gai +5 more
semanticscholar +6 more sources
Metabolic engineering for increased lipid accumulation in Yarrowia lipolytica - A Review.
Bioresource Technology, 2020 Current energy security and climate change policies encourage the development and utilization of bioenergy. Oleaginous yeasts provide a particularly attractive platform for the sustainable production of biofuels and industrial chemicals due to their ...
Jinpeng Wang +4 more
semanticscholar +3 more sources
Lipid accumulation and oxidation in glioblastoma multiforme [PDF]
Scientific Reports, 2019 Glioblastoma multiforme (GBM) is the most common and lethal primary malignant brain tumor in adults. Despite the multimodal standard treatments for GBM, the median survival is still about one year.
Bouchra Taïb +6 more
semanticscholar +3 more sources
Lipid Droplet Accumulation Promotes RPE Dysfunction [PDF]
International Journal of Molecular Sciences, 2022 Non-exudative age-related macular degeneration (AMD) is an irreversibly progressive retinal degenerative disease characterized by dysfunction and loss of retinal pigment epithelium (RPE). It has been suggested that impaired phagocytosis of the RPE is involved in the progression of non-exudative AMD, but the mechanism is not fully clear.
Tomohiro Yako +4 more
openaire +2 more sources
Astrocytes in stress accumulate lipid droplets [PDF]
Glia, 2021 AbstractWhen the brain is in a pathological state, the content of lipid droplets (LDs), the lipid storage organelles, is increased, particularly in glial cells, but rarely in neurons. The biology and mechanisms leading to LD accumulation in astrocytes, glial cells with key homeostatic functions, are poorly understood.
Tina Smolič +11 more
openaire +2 more sources
BRAF Modulates Lipid Use and Accumulation
Cancers, 2022 There is increasing evidence that oxidative metabolism and fatty acids play an important role in BRAF-driven tumorigenesis, yet the effect of BRAF mutation and expression on metabolism is poorly understood. We examined how BRAF mutation and expression modulates metabolite abundance.
Jacqueline A. Turner +12 more
openaire +2 more sources
Lipid metabolism and accumulation in oilseed crops [PDF]
OCL, 2021 Triacylglycerols (TAGs) serve as the most important storage form of energy and carbon in eukaryotic cells and thus are one of the fundamental macronutrients for animal and human diet. They are also used as a major feedstock for diverse industrial and energetic sectors due to their high energy density. Oilseed crops represent the most valuable source of
Miklaszewska, Magdalena +3 more
openaire +4 more sources
Human resistin promotes macrophage lipid accumulation [PDF]
Diabetologia, 2006 The gene encoding resistin/FIZZ3 (found in inflammatory zone 3), which is denoted by the gene symbol RETN in humans and Retn in mice, belongs to a new gene family of small cysteine-rich secretory proteins, called ‘resistin-like molecules’, originally discovered in a search for adipocytederived molecules linking obesity and insulin-resistant diabetes [1]
Rae, C., Graham, Annette
openaire +2 more sources
Cell Reports, 2020 Summary: Obesity leads to a state of chronic, low-grade inflammation that features the accumulation of lipid-laden macrophages in adipose tissue. Here, we determined the role of macrophage lipid-droplet accumulation in the development of obesity-induced ...
Xanthe A.M.H. van Dierendonck +9 more
doaj +1 more source
Apigenin ameliorates hepatic lipid accumulation by activating the autophagy-mitochondria pathway
Journal of Food and Drug Analysis, 2021 Apigenin, a flavonoid isolated from plants, provides protection against non-alcoholic fatty liver disease. However, the mechanism by which apigenin decreases lipid accumulation in the liver is unclear.
Man-Chen Hsu +4 more
semanticscholar +1 more source