Results 131 to 140 of about 3,287,800 (353)

Ganoderma lucidum Spore Powder Alleviates Metabolic-Associated Fatty Liver Disease by Improving Lipid Accumulation and Oxidative Stress via Autophagy

Antioxidants
Lipid accumulation and oxidative stress, which could be improved by autophagy, are the “hits” of metabolic-associated fatty liver disease (MAFLD). Ganoderma lucidum spore powder (GLSP) has the effect of improving liver function.
Yuxuan Zhang, Jiali Zhou, Lan Yang, Hang Xiao, Dongbo Liu, Xincong Kang   +5 more
doaj   +1 more source

An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo

Science Translational Medicine, 2018
A nanoreporter noninvasively detects endolysosomal lipids, revealing that short-term changes in diet have enduring effects on hepatic macrophages.
Thomas V. Galassi, Prakrit V. Jena, Janki Shah, Geyou Ao, Elizabeth A. Molitor, Y. Bram, Angela S. Frankel, Jiwoon Park, J. Jessurun, D. Ory, A. Haimovitz-Friedman, Daniel Roxbury, J. Mittal, M. Zheng, R. Schwartz, D. Heller   +15 more
semanticscholar   +1 more source

Mutations in UDP-Glucose:Sterol Glucosyltransferase in Arabidopsis Cause Transparent Testa Phenotype and Suberization Defect in Seeds [PDF]

, 2009
In higher plants, the most abundant sterol derivatives are steryl glycosides (SGs) and acyl SGs. Arabidopsis (Arabidopsis thaliana) contains two genes, UGT80A2 and UGT80B1, that encode UDP-Glc:sterol glycosyltransferases, enzymes that catalyze the ...
Auer, Manfred, Beisson, Fred, Bischoff, Volker, Bouvier-Navé, Pierrette, Carroll, Andrew, DeBolt, Seth, Hematy, Kian, Li, Yonghua, Milne, Jennifer, Nair, Meera, Schaller, Hubert, Scheible, Wolf-Rüdiger, Schrick, Kathrin, Somerville, Chris, Zemla, Marcin   +14 more
core   +5 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Growth kinetics, fatty acid composition and metabolic activity changes of Crypthecodinium cohnii under different nitrogen source and concentration

AMB Express, 2017
The effect of varying concentrations of the nitrogen source on the growth kinetics, lipid accumulation, lipid and DHA productivity, and fatty acid composition of C. cohnii was elucidated. Growth of C.
Waseem Safdar, Muhammad Shamoon, Xinyi Zan, Junaid Haider, Hafiz Rizwan Sharif, Muhammad Shoaib, Yuanda Song   +6 more
doaj   +1 more source

Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells [PDF]

, 2019
Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus.
Caridis, Anna Maria, Dolan, Sharron, Graham, Annette, Lightbody, Richard J., Tarlton, Jamie M.R.   +4 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

LipiD-QuanT: a novel method to quantify lipid accumulation in live cells[S]

Journal of Lipid Research, 2015
Lipid droplets (LDs) are the main storage organelles for triglycerides. Elucidation of lipid accumulation mechanisms and metabolism are essential to understand obesity and associated diseases. Adipogenesis has been well studied in murine 3T3-L1 and human
Hilal Varinli, Megan J. Osmond-McLeod, Peter L. Molloy, Pascal Vallotton   +3 more
doaj   +1 more source

Effects of sodium bicarbonate on cell growth, lipid accumulation, and morphology of Chlorella vulgaris

Microbial Cell Factories, 2018
BackgroundLow concentration NaHCO3 (ca. 12 mM) had been demonstrated to be an excellent carbon source for industrially important green alga Chlorella vulgaris and high concentration NaHCO3 (e.g.
Jingya Li, Changhao Li, C. Lan, Dankui Liao   +3 more
semanticscholar   +1 more source

Renal Lipid Accumulation in Human Obesity

The FASEB Journal, 2013
In obesity and the metabolic syndrome, lipid accumulation in several non‐adipose tissues has been implicated in the pathogenesis of tissue and organ dysfunction. Whether obesity is associated with lipid accumulation in the human kidney remains uncertain.
Ion Alexandru Bobulescu, Tara Rosenthal, Hillary Thompson, Khashayar Sakhaee, Orson W Moe   +4 more
openaire   +1 more source