Results 281 to 290 of about 858,616 (357)

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

MicroRNA-18a-5p regulates hepatic lipid accumulation in response to high-fat diet. [PDF]

Front Physiol
Petito G, Magnacca N, Cuomo A, Ventriglia M, Fusco A, Venditti M, Falvo S, Potenza N, Lanni A, Cioffi F, Senese R.   +10 more
europepmc   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Lipid accumulation in nitrogen and phosphorus-limited yeast is caused by less growth-related dilution. [PDF]

Metab Eng
Li X, Weilandt DR, Keber FC, Subramanian AM, Loynes SR, Rao CV, Shen Y, Wühr M, Rabinowitz JD.   +8 more
europepmc   +1 more source

The Dopaminergic Activation Counteracts Adipose and Skeletal Muscle Lipid Accumulation by Promoting Fat Oxidation: A Novel Therapeutic Approach to Obesity?

Mariarosaria Negri, Claudia Pivonello, Renata S. Auriemma, Feliciana Amatrudo, Donatella Paola Provvisiero, Roberta Patalano, Maria Anna Marciano, Guendalina Del Vecchio, Laura Rinaldi, Davide Menafra, Antonio Feliciello, Annamaria Colao, Raffaella Crescenzo, Rosario Pivonello   +13 more
openalex   +1 more source

Metallofullerenol Sc3N@C80(OH)18: A New Generation Radioprotector Protecting Human Erythrocytes Against Multiple Biochemical Damage Modes Upon Gamma Irradiation, Identifying It as a Scavenger of Short‐ and Long‐Lived Radicals

Advanced Healthcare Materials, EarlyView.
Metallofullerenol Sc3N@C80(OH)18 demonstrates strong radioprotective properties as a scavenger of both short‐ and long‐lived radicals. The study reveals protection of human erythrocytes from γ‐radiation–induced biochemical damage via post‐irradiation removal of primary and secondary reactive oxidants, supported by pulse radiolysis kinetics.
Jacek Grebowski, Maciej Studzian, Szymon Lekki‐Porebski, Anna Konarska, Marian Wolszczak, Grzegorz Litwinienko, Lukasz Pulaski   +6 more
wiley   +1 more source

Geranylgeranyl Pyrophosphate Promotes Hepatic Lipid Accumulation by Prenylation of Perilipin4. [PDF]

Cell Mol Gastroenterol Hepatol
Zhao Y, Nie HY, Jiang S, Zhao MF, Sun P, Zhang JZ, Wang XC, Tang YP, Zou MJ, Yuan XW, Sun XT, Shan XD, He J, Liu JH, Bi Y, Fang L, Han X, Li CJ.   +17 more
europepmc   +1 more source

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

Soluble Dietary Fiber from Highland Barley Bran Reduces Hepatic Lipid Accumulation in Mice via Gut Microbiota Modulation. [PDF]

Nutrients
Wei X, Lang F, Liu H, Wang S, Wang T.
europepmc   +1 more source