The pleiotropic transcriptional regulator NlpR contributes to the modulation of nitrogen metabolism, lipogenesis and triacylglycerol accumulation in oleaginous rhodococci [PDF]
, 2017 The regulatory mechanisms involved in lipogenesis and triacylglycerol (TAG) accumulation are largely unknown in oleaginous rhodococci. In this study a regulatory protein (here called NlpR: Nitrogen lipid Regulator), which contributes to the modulation of
Alvarez, Hector Manuel +4 more
core +1 more source
TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. [PDF]
, 2014 In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy.
Seki, Ekihiro
core +2 more sources
Secondary lipid accumulation in lysosomal disease
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009 Lysosomal diseases are inherited metabolic disorders caused by defects in a wide spectrum of lysosomal and a few non-lysosomal proteins. In most cases a single type of primary storage material is identified, which has been used to name and classify the disorders: hence the terms sphingolipidoses, gangliosidoses, mucopolysaccharidoses, glycoproteinoses,
Walkley, Steven U., Vanier, Marie T.
openaire +2 more sources
Inhibitory effects of compounds from the roots of Potentilla longifolia on lipid accumulation
PLoS ONE, 2020 Potentilla longifolia is a kind of Chaoyao medicine, which is a branch of traditional Chinese medicine. The plant is often referred to as ganyancao or ganyearmcao, which means that it has a significant therapeutic effect on liver inflammation.
Shengxi Lin +9 more
doaj +2 more sources
Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease
Cellular and Molecular Life Sciences, 2018 Non-alcoholic fatty liver disease (NAFLD) is currently the world’s most common liver disease, estimated to affect up to one-fourth of the population.
D. H. Ipsen +2 more
semanticscholar +1 more source
Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration. [PDF]
, 2015 Background & aimsAll-trans Retinoic acid (RA) regulates hepatic lipid and bile acid homeostasis. Similar to bile acid (BA), RA accelerates partial hepatectomy (PHx)-induced liver regeneration.
Hu, Ying +2 more
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Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and vitro
Food Science and Human Wellness, 2023 The aim of this study was to explore the lipid-lowering effect of naringenin and the underlying mechanism in high-fat-diet-fed SD rats and 3T3-L1 cells. In this study, SD rats were divided into the normal chow diet group (NCD), high fat diet group (HFD),
Xiaoyu Cai +7 more
doaj +1 more source
Lipid accumulation in macrophages confers protumorigenic polarization and immunity in gastric cancer
Cancer Science, 2020 Heterotypic interactions between tumor cells and macrophages can enable tumor progression and hold potential for the development of therapeutic interventions.
Qin Luo +13 more
semanticscholar +1 more source
Targeting MicroRNAs to Limit Myocardial Lipid Accumulation [PDF]
Circulation Research, 2015 Obesity and type 2 diabetes mellitus are major health concerns, with the incidence rapidly rising in the world. Among their many complications is an increased risk of developing heart failure.1,2 This increased incidence of heart failure in obese and diabetic individual occurs even when corrected for the increased prevalence of hypertension and ...
Gary D, Lopaschuk, John R, Ussher
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Frontiers in Endocrinology, 2023 AimConfirm and compare the degree of associations of non-traditional lipid profiles and metabolic syndrome (MetS) in Chinese adolescents, determine the lipid parameter with better predictive potential, and investigate their discriminatory power on MetS ...
Zi-yi Chen +6 more
doaj +1 more source