Results 271 to 280 of about 199,961 (298)
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Structure and Biology of Self Lipid Antigens
2007Self lipid antigens induce selection and expansion of autoreactive T cells which have a role in immunoregulation and disease pathogenesis. Here we review the important biological rules which determine lipid immunogenicity. The impact of lipid structure, synthesis, traffic, membrane distribution and CD1 loading are discussed.
G, De Libero, L, Mori
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How T cells get grip on lipid antigens
Current Opinion in Immunology, 2008Lipid antigens are presented to T cells as complexes formed with CD1 family members. The hydrophobic nature of lipids influences how they remain in biological fluids, are distributed within cells, and are handled to become immunogenic. Continuously expanding knowledge shows how lipids are internalized by APC, traffic through the endocytic system, are ...
De Libero, G., Mori, L.
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The CD1 family of lipid antigen-presenting molecules
Immunology Today, 1998Abstract The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting
S A, Porcelli +4 more
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Lipid metabolism, atherogenesis and CD1-restricted antigen presentation
Trends in Molecular Medicine, 2006CD1 molecules are a family of major histocompatibility complex (MHC)-related glycoproteins that present lipid and glycolipid antigens to T cells. Interestingly, it has been demonstrated that CD1d-restricted T cells have a pathogenic role in atherosclerosis.
Amy S, Major +2 more
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Presentation of bacterial lipid antigens by CD1 molecules
Trends in Microbiology, 1998Human CD1 molecules bind and display or present lipid and glycolipid antigens from mycobacteria for recognition by T cells. Presentation requires uptake of antigen into endosomes, where it binds to CD1. T-cell recognition of CD1-presented nonpeptide antigens is a newly defined immune response that could be important for host defense against a variety ...
T I, Prigozy, M, Kronenberg
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CD1d-dependent endogenous and exogenous lipid antigen presentation
Current Opinion in Immunology, 2015Invariant natural killer T (iNKT) cells recognize endogenous and exogenous lipids in the context of CD1d molecules, and through the activation and maturation of dendritic cells and B cells, can significantly enhance priming of antigen-specific T and B cell responses. Recent findings have provided important insights into the recognition of several novel
Rosanna M, McEwen-Smith +2 more
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Gravimetric antigen detection utilizing antibody-modified lipid bilayers
Analytical Biochemistry, 2005Lipid bilayers containing 5% nitrilotriacetic acid (NTA) lipids supported on SiO2 have been used as a template for immobilization of oligohistidine-tagged single-chained antibody fragments (scFvs) directed against cholera toxin. It was demonstrated that histidine-tagged scFvs could be equally efficiently coupled to an NTA-Ni2+-containing lipid bilayer ...
Charlotte, Larsson +4 more
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