Advancements in nanomaterial-based adjuvants for animal vaccines. [PDF]
Dai L +7 more
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Metabolic Checkpoints and Lymphoid Neogenesis in Lung Dendritic Cells: Mechanisms Guiding Tolerance and Chronic Lung Inflammation. [PDF]
Fonseca-Balladares DC +6 more
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Tiny packages, big potential: bacterial membrane vesicles in vaccinology. [PDF]
Varol A +3 more
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Reprogramming the tumor microenvironment through vaccine strategies to improve clinical outcomes and guide future innovations. [PDF]
Mohammadi A.
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Harnessing pre-existing measles immunity: mRNA-Lipid nanoparticle-mediated measles hemagglutinin expression boosts antitumor CD8⁺ T cell responses. [PDF]
Martínez-Latorre J +6 more
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Repurposing COVID-19 (and other) mRNA vaccines to boost cancer immunotherapy efficacy: mechanistic insights and future directions. [PDF]
Gujar S +6 more
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Presentation of lipid antigens to T cells
T cells specific for lipid antigens participate in regulation of the immune response during infections, tumor immunosurveillance, allergy and autoimmune diseases. T cells recognize lipid antigens as complexes formed with CD1 antigen-presenting molecules, thus resembling recognition of MHC-peptide complexes.
Lucia Mori, Gennaro De Libero
exaly +5 more sources
T cells specific for lipid antigens
Lipid-specific T cells are important participants in human immune responses. Recognition of lipid antigens contributes to host defense against pathogens that can cause debilitating diseases, including mycobacterial, viral, and parasitic infections. Lipid-specific T cells also play important roles in various autoimmune diseases, atherosclerosis, and in ...
Lucia Mori +2 more
exaly +5 more sources
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Recognition of lipid antigens by T cells
Nature Reviews Immunology, 2005Recent studies have shown that the recognition of lipid antigens by the immune system is important for defence against infection and other diseases, and that lipid-specific responses occur at higher frequencies than previously suspected. Thanks to several recent advances in this field, we now have a better appreciation of the molecular and cellular ...
Gennaro De Libero +2 more
exaly +4 more sources
How the immune system detects lipid antigens
T lymphocytes are the cells of the immune system that may recognize glycolipids as antigens. T cells recognize lipids associated with the non-polymorphic molecules of the CD1 family present on the membrane of antigen-presenting cells. CD1 molecules contain hydrophobic pockets, which bind a large variety of lipid molecules in various manners.
De Libero, Gennaro, Mori, Lucia
openaire +5 more sources

