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Multigenic single-chain mRNA vaccine provides full protection against <i>Dabie bandavirus</i> infection. [PDF]

open access: yesMol Ther Nucleic Acids
Costa da Silva GH   +2 more
europepmc   +1 more source
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Apolipoprotein-mediated pathways of lipid antigen presentation

Nature, 2005
Peptide antigens are presented to T cells by major histocompatibility complex (MHC) molecules, with endogenous peptides presented by MHC class I and exogenous peptides presented by MHC class II. In contrast to the MHC system, CD1 molecules bind lipid antigens that are presented at the antigen-presenting cell (APC) surface to lipid antigen-reactive T ...
Peter, van den Elzen   +13 more
openaire   +4 more sources

Recognition of lipid antigens by T cells

Nature Reviews Immunology, 2005
Recent studies have shown that the recognition of lipid antigens by the immune system is important for defence against infection and other diseases, and that lipid-specific responses occur at higher frequencies than previously suspected. Thanks to several recent advances in this field, we now have a better appreciation of the molecular and cellular ...
Gennaro, De Libero, Lucia, Mori
openaire   +4 more sources

Lipid Metabolism and Tumor Antigen Presentation

2021
Tumors always evade immune surveillance and block T cell activation in a poorly immunogenic and immunosuppressive environment. Cancer cells and immune cells exhibit metabolic reprogramming in the tumor microenvironment (TME), which intimately links immune cell function and edits tumor immunology.
Hong, Qin, Yaxi, Chen
openaire   +2 more sources

Lipid-Modified Antigens

The Journal of Immunology, 1979
Abstract Dodecanoic acid side chains were coupled to the antigen 2,4-dinitrophenyl-bovine serum albumin (DNP-BSA) to make DNP-BSA-lipid. T cells from guinea pigs primed with DNP-BSA-lipid proliferate in vitro when stimulated by most, but not all, DNP-carrier conjugates.
C A Janeway   +4 more
openaire   +1 more source

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