Results 261 to 270 of about 199,961 (298)

CD1 and lipid antigens: intracellular pathways for antigen presentation

Current Opinion in Immunology, 2001
Recently, different members of the CD1 family of MHC-like molecules have been shown to sample different intracellular compartments to present lipid and glycolipid antigens to T cells. Emerging models suggest that CD1 may have evolved to monitor the integrity of membrane lipids and/or to present microbial lipid antigens to both alpha beta and gamma ...
J, Jayawardena-Wolf, A, Bendelac
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T cells specific for lipid antigens

Immunologic Research, 2012
Lipid-specific T cells are important participants in human immune responses. Recognition of lipid antigens contributes to host defense against pathogens that can cause debilitating diseases, including mycobacterial, viral, and parasitic infections. Lipid-specific T cells also play important roles in various autoimmune diseases, atherosclerosis, and in ...
Mori, L., De Libero, G.
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Anatomy of CD1–lipid antigen complexes

Nature Reviews Immunology, 2005
CD1 proteins bind lipids to form antigen complexes that contact T-cell receptors and activate T cells. Recent crystal structures of CD1 proteins show that their antigen-binding grooves are composed of up to four pockets (A', C', F' and T') and two antigen portals (C' and F').
D Branch, Moody, Dirk M, Zajonc, Ian A, Wilson   +2 more
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Novel insights into lipid antigen presentation

Trends in Immunology, 2012
T cells recognizing lipid antigens are present in large numbers in circulating blood. They exert multiple functions including immunoregulation, tumour surveillance and protection during infection. Here, we review the latest information on the mechanisms of lipid antigen presentation by CD1 molecules.
De Libero, G., Mori, L.
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Lipid-Protamine-DNA-Mediated Antigen Delivery

Current Drug Delivery, 2005
The development of novel 'new generation' vaccine systems that is based on proteins, peptides or DNA is of great current interest. However, due to the lower efficiencies of these new generation vaccines, they are seldomly used alone. Rather, their formulations often contain adjuvants, either to enhance the immune responses or to reduce dosing.
Dileep Padinjarae, Vangasseri, Su-Ji, Han, Leaf, Huang   +2 more
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Lipid-based antigen delivery systems

Journal of Pharmaceutical Investigation, 2016
Lipid-based carriers, including liposomes and emulsions, have been studied as antigen delivery systems to improve humoral and cellular immune responses. Lipid-based delivery systems have been tailored based on the physicochemical properties of antigens and administration routes.
Joo Yeon Park, Mi-Gyeong Kim, Gayong Shim, Yu-Kyoung Oh   +3 more
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Presentation of lipid antigens to T cells

Immunology Letters, 2008
T cells specific for lipid antigens participate in regulation of the immune response during infections, tumor immunosurveillance, allergy and autoimmune diseases. T cells recognize lipid antigens as complexes formed with CD1 antigen-presenting molecules, thus resembling recognition of MHC-peptide complexes.
Mori, L., De Libero, G.
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Cationic supported lipid bilayers for antigen presentation

International Journal of Pharmaceutics, 2007
Polystyrene sulfate (PSS) particles (301 nm mean diameter) were covered with single cationic dioctadecyldimethylammonium bromide (DDA) bilayers and used for antigen adsorption and presentation. The antigen was a mixture of purified 18/14 Taenia crassiceps proteins (18/14-Tcra).
N, Lincopan, N M, Espíndola, A J, Vaz, A M, Carmona-Ribeiro   +3 more
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How the immune system detects lipid antigens

Progress in Lipid Research, 2010
T lymphocytes are the cells of the immune system that may recognize glycolipids as antigens. T cells recognize lipids associated with the non-polymorphic molecules of the CD1 family present on the membrane of antigen-presenting cells. CD1 molecules contain hydrophobic pockets, which bind a large variety of lipid molecules in various manners.
De Libero, Gennaro, Mori, Lucia
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Lipid A and liposomes containing lipid A as antigens and adjuvants

Vaccine, 2008
Lipid A derived from Gram-negative bacterial lipopolysaccharide is a potent adjuvant and antigen. Incorporation of lipid A into liposomes renders the liposomes themselves immunogenic, resulting in generation of specific antibodies that recognize either the individual liposomal lipids, or the unique pattern presented by the combination of lipids.
Carl R, Alving, Mangala, Rao
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