Results 261 to 270 of about 118,445 (283)

Apolipoprotein-mediated pathways of lipid antigen presentation

Nature, 2005
Peptide antigens are presented to T cells by major histocompatibility complex (MHC) molecules, with endogenous peptides presented by MHC class I and exogenous peptides presented by MHC class II. In contrast to the MHC system, CD1 molecules bind lipid antigens that are presented at the antigen-presenting cell (APC) surface to lipid antigen-reactive T ...
Peter, van den Elzen, Salil, Garg, Luis, León, Manfred, Brigl, Elizabeth A, Leadbetter, Jenny E, Gumperz, Chris C, Dascher, Tan-Yun, Cheng, Frank M, Sacks, Petr A, Illarionov, Gurdyal S, Besra, Sally C, Kent, D Branch, Moody, Michael B, Brenner   +13 more
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Lipid A and liposomes containing lipid A as antigens and adjuvants

Vaccine, 2008
Lipid A derived from Gram-negative bacterial lipopolysaccharide is a potent adjuvant and antigen. Incorporation of lipid A into liposomes renders the liposomes themselves immunogenic, resulting in generation of specific antibodies that recognize either the individual liposomal lipids, or the unique pattern presented by the combination of lipids.
Carl R, Alving, Mangala, Rao
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Lipid Metabolism and Tumor Antigen Presentation

2021
Tumors always evade immune surveillance and block T cell activation in a poorly immunogenic and immunosuppressive environment. Cancer cells and immune cells exhibit metabolic reprogramming in the tumor microenvironment (TME), which intimately links immune cell function and edits tumor immunology.
Hong, Qin, Yaxi, Chen
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Lipid-Modified Antigens

The Journal of Immunology, 1979
Abstract Dodecanoic acid side chains were coupled to the antigen 2,4-dinitrophenyl-bovine serum albumin (DNP-BSA) to make DNP-BSA-lipid. T cells from guinea pigs primed with DNP-BSA-lipid proliferate in vitro when stimulated by most, but not all, DNP-carrier conjugates.
C A Janeway, M Horowitz, M O Dailey, R A Hunter, H Wigzell   +4 more
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CD1 and lipid antigens: intracellular pathways for antigen presentation

Current Opinion in Immunology, 2001
Recently, different members of the CD1 family of MHC-like molecules have been shown to sample different intracellular compartments to present lipid and glycolipid antigens to T cells. Emerging models suggest that CD1 may have evolved to monitor the integrity of membrane lipids and/or to present microbial lipid antigens to both alpha beta and gamma ...
J, Jayawardena-Wolf, A, Bendelac
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Novel insights into lipid antigen presentation

Trends in Immunology, 2012
T cells recognizing lipid antigens are present in large numbers in circulating blood. They exert multiple functions including immunoregulation, tumour surveillance and protection during infection. Here, we review the latest information on the mechanisms of lipid antigen presentation by CD1 molecules.
De Libero, G., Mori, L.
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Anatomy of CD1–lipid antigen complexes

Nature Reviews Immunology, 2005
CD1 proteins bind lipids to form antigen complexes that contact T-cell receptors and activate T cells. Recent crystal structures of CD1 proteins show that their antigen-binding grooves are composed of up to four pockets (A', C', F' and T') and two antigen portals (C' and F').
D Branch, Moody, Dirk M, Zajonc, Ian A, Wilson   +2 more
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Structure and Biology of Self Lipid Antigens

2007
Self lipid antigens induce selection and expansion of autoreactive T cells which have a role in immunoregulation and disease pathogenesis. Here we review the important biological rules which determine lipid immunogenicity. The impact of lipid structure, synthesis, traffic, membrane distribution and CD1 loading are discussed.
De Libero G, Mori L
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Lipid based particulate formulations for the delivery of antigen

Immunology & Cell Biology, 2005
Particulate adjuvant systems are largely classified according to their functional characteristics, such as the nature of the typical immune response they induce, or their perceived mode of action. From a formulation science perspective, it is practical to classify antigen delivery systems according to the physical nature of the formulations.
Copland, Melissa J., Rades, Thomas, Davies, Nigel M., Baird, Margaret A.   +3 more
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The CD1 family of lipid antigen-presenting molecules

Immunology Today, 1998
Abstract The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting
S A, Porcelli, B W, Segelke, M, Sugita, I A, Wilson, M B, Brenner   +4 more
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