Results 241 to 250 of about 199,961 (298)

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Advances in delivery technologies-powered cancer vaccines. [PDF]

Bioact Mater
Huang C, Wang H, Luo S, Yu C, Zhang L, Zhu D.   +5 more
europepmc   +1 more source

[Coprecipitation of bacterial antigens and lipids].

Medycyna doswiadczalna i mikrobiologia, 2003
A W, KOZINSKI, E, MIKULASZEK, Z, OPARA
openaire   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

A Bioinspired Approach to Next-Generation Vaccines in Solid Tumors with Engineered Cell Membranes. [PDF]

Research (Wash D C)
Zhang W, Chen M, Huang X.
europepmc   +1 more source

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, EarlyView.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source

Sideways lipid presentation by the antigen-presenting molecule CD1c. [PDF]

Nat Commun
Cao TP, Liao GR, Cheng TY, Chen Y, Ciacchi L, Fulford TS, Farquhar R, Kollmorgen J, Mayfield JA, Uldrich AP, Ng EZQ, Ogg GS, Godfrey DI, Gherardin NA, Chen YL, Moody DB, Shahine A, Rossjohn J.   +17 more
europepmc   +1 more source

Alcaligenes lipid A as a sublingual adjuvant to augment protective immune responses in the respiratory and gastrointestinal tracts. [PDF]

Int Immunol
Yoshii K, Liu Z, Shimoyama A, Hirayama Y, Iemitsu K, Node E, Hosomi K, Kiyono H, Fukase K, Kunisawa J.   +9 more
europepmc   +1 more source

γδ T cell receptor recognition of CD1d in a lipid-independent manner. [PDF]

Nat Commun
Rice MT, Gunasinghe SD, Sok CL, Pan M, Lay CS, Gully BS, Rossjohn J.   +6 more
europepmc   +1 more source