Results 11 to 20 of about 219,006 (336)
A quantitative analysis of ligand binding at the protein-lipid bilayer interface [PDF]
Communications ChemistryThe majority of drugs target membrane proteins, and many of these proteins contain ligand binding sites embedded within the lipid bilayer. However, targeting these therapeutically relevant sites is hindered by limited characterization of both the sites ...
Allison Pearl Barkdull +2 more
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Lipid bilayer hydrodynamic drag [PDF]
Physical Review Research, 2020 The hydrodynamic drag at a lipid bilayer surface determines in part the flow properties of suspensions of cells and liposomes. Given the fluidity of lipid bilayers, it is not obvious a priori whether boundary conditions like those of solid objects in ...
Philip E. Jahl, Raghuveer Parthasarathy
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Functional regulation of aquaporin dynamics by lipid bilayer composition [PDF]
Nature CommunicationsWith the diversity of lipid-protein interactions, any observed membrane protein dynamics or functions directly depend on the lipid bilayer selection.
Anh T. P. Nguyen +2 more
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Structure determination of lipid bilayers
Biophysical Journal, 1978 A method of determining the phases of X-ray reflections from oriented model membrane systems at low resolution is described. The method involves deconvolution and requires that d less than or equal to 2v where v is the width of the head group region within the bilayer and d is the thickness of the bilayer.
C.R. Worthington, R.S. Kharf
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Biophysica, 2023 The interaction of many peptides with lipid bilayer membranes strongly depends on the lipid composition. Here, a study of the impact of unsaturated lipid acyl chains on the interaction of a derivative of the HIV-1 fusion peptide with lipid bilayer ...
William T. Heller, Piotr A. Zolnierczuk
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Water Pores in Planar Lipid Bilayers at Fast and Slow Rise of Transmembrane Voltage
Membranes, 2021 Basic understanding of the barrier properties of biological membranes can be obtained by studying model systems, such as planar lipid bilayers. Here, we study water pores in planar lipid bilayers in the presence of transmembrane voltage.
Alenka Maček Lebar +3 more
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Structure of lipid bilayers [PDF]
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 2000 The quantitative experimental uncertainty in the structure of fully hydrated, biologically relevant, fluid (L(alpha)) phase lipid bilayers has been too large to provide a firm base for applications or for comparison with simulations. Many structural methods are reviewed including modern liquid crystallography of lipid bilayers that deals with the fully
John F. Nagle, Stephanie Tristram-Nagle
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Biophysica, 2023 Understanding the membrane interactions of the N-terminal 17 residues of the huntingtin protein (HttN) is essential for unraveling its role in cellular processes and its impact on huntingtin misfolding. In this study, we used atomic force microscopy (AFM)
Yasith Indigahawela Gamage, Jianjun Pan
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Current Opinion in Structural Biology, 2000 Fluctuations, inherent in flexible and biologically relevant lipid bilayers, make quantitative structure determination challenging. Shortcomings in older methods of structure determination have been realized and new methodologies have been introduced that take fluctuations into account.
John F. Nagle, Stephanie Tristram-Nagle
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DNA-nanostructure-templated assembly of planar and curved lipid-bilayer membranes
Frontiers in Chemistry, 2023 Lipid-bilayer nanodiscs and liposomes have been developed to stabilize membrane proteins in order to study their structures and functions. Nanodiscs are detergent-free, water-soluble, and size-controlled planar phospholipid-bilayer platforms.
Mostafa A. Elbahnasawy, Mahmoud L. Nasr
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