Results 11 to 20 of about 229,223 (348)

A quantitative analysis of ligand binding at the protein-lipid bilayer interface [PDF]

Communications Chemistry
The majority of drugs target membrane proteins, and many of these proteins contain ligand binding sites embedded within the lipid bilayer. However, targeting these therapeutically relevant sites is hindered by limited characterization of both the sites ...
Allison Pearl Barkdull, Matthew Holcomb, Stefano Forli   +2 more
doaj   +2 more sources

Functional regulation of aquaporin dynamics by lipid bilayer composition [PDF]

Nature Communications
With the diversity of lipid-protein interactions, any observed membrane protein dynamics or functions directly depend on the lipid bilayer selection.
Anh T. P. Nguyen, Austin T. Weigle, Diwakar Shukla   +2 more
doaj   +2 more sources

The Interaction of the Transmembrane Domain of SARS-CoV-2 E-Protein with Glycyrrhizic Acid in Lipid Bilayer [PDF]

Membranes, 2023
The interaction of the transmembrane domain of SARS-CoV-2 E-protein with glycyrrhizic acid in a model lipid bilayer (small isotropic bicelles) is demonstrated using various NMR techniques.
Polina A. Kononova, Olga Yu. Selyutina, Nikolay E. Polyakov   +2 more
doaj   +2 more sources

Allosteric coupling between a lipid bilayer and a membrane protein. [PDF]

Biophys J
Fourel C, Gautier Y, Pozza A, Giraud F, Point E, Le Bon C, Moncoq K, Stirnemann G, Hénin J, Lescop E, Catoire LJ.   +10 more
europepmc   +2 more sources

Investigation of the Impact of Lipid Acyl Chain Saturation on Fusion Peptide Interactions with Lipid Bilayers

Biophysica, 2023
The interaction of many peptides with lipid bilayer membranes strongly depends on the lipid composition. Here, a study of the impact of unsaturated lipid acyl chains on the interaction of a derivative of the HIV-1 fusion peptide with lipid bilayer ...
William T. Heller, Piotr A. Zolnierczuk
doaj   +1 more source

Water Pores in Planar Lipid Bilayers at Fast and Slow Rise of Transmembrane Voltage

Membranes, 2021
Basic understanding of the barrier properties of biological membranes can be obtained by studying model systems, such as planar lipid bilayers. Here, we study water pores in planar lipid bilayers in the presence of transmembrane voltage.
Alenka Maček Lebar, Damijan Miklavčič, Malgorzata Kotulska, Peter Kramar   +3 more
doaj   +1 more source

Lipid bilayer structure [PDF]

Current Opinion in Structural Biology, 2000
Fluctuations, inherent in flexible and biologically relevant lipid bilayers, make quantitative structure determination challenging. Shortcomings in older methods of structure determination have been realized and new methodologies have been introduced that take fluctuations into account.
J F, Nagle, S, Tristram-Nagle
openaire   +2 more sources

Elucidating the Influence of Lipid Composition on Bilayer Perturbations Induced by the N-Terminal Region of the Huntingtin Protein

Biophysica, 2023
Understanding the membrane interactions of the N-terminal 17 residues of the huntingtin protein (HttN) is essential for unraveling its role in cellular processes and its impact on huntingtin misfolding. In this study, we used atomic force microscopy (AFM)
Yasith Indigahawela Gamage, Jianjun Pan
doaj   +1 more source

DNA-encircled lipid bilayers [PDF]

Nanoscale, 2018
We describe a method to harness the programmability of DNA nanotechnology to create DNA-encircled lipid bilayers.
Katarina Iric, Madhumalar Subramanian, Jana Oertel, Nayan P. Agarwal, Michael Matthies, Xavier Periole, Thomas P. Sakmar, Thomas Huber, Karim Fahmy, Thorsten L. Schmidt   +9 more
openaire   +6 more sources

DNA-nanostructure-templated assembly of planar and curved lipid-bilayer membranes

Frontiers in Chemistry, 2023
Lipid-bilayer nanodiscs and liposomes have been developed to stabilize membrane proteins in order to study their structures and functions. Nanodiscs are detergent-free, water-soluble, and size-controlled planar phospholipid-bilayer platforms.
Mostafa A. Elbahnasawy, Mahmoud L. Nasr
doaj   +1 more source