Results 61 to 70 of about 199,281 (229)

Phase Separation of Saturated and Mono-unsaturated Lipids as determined from a Microscopic Model

, 2004
A molecular model is proposed of a bilayer consisting of fully saturated DPPC and mono unsaturated DOPC. The model not only encompasses the constant density within the hydrophobic core of the bilayer, but also the tendency of chain segments to align.
Elliott, R., Katsov, K., Schick, M., Szleifer, I.   +3 more
core   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Structural Effects of Small Molecules on Phospholipid Bilayers Investigated by Molecular Simulations

, 2004
We summarize and compare recent Molecular Dynamics simulations on the interactions of dipalmitoylphosphatidylcholine (DPPC) bilayers in the liquid crystalline phase with a number of small molecules including trehalose, a disaccharide of glucose, alcohols,
Faller, Roland, Karttunen, Mikko, Lee, Bryan W., Patra, Michael, Sum, Amadeu K., Vattulainen, Ilpo   +5 more
core   +2 more sources

Polydopamine-Supported Lipid Bilayers

Materials, 2012
We report the formation of lipid membranes supported by a soft polymeric cushion of polydopamine. First, 20 nm thick polydopamine films were formed on mica substrates. Atomic force microscopy imaging indicated that these films were also soft with a surface roughness of 2 nm under hydrated conditions.
Jerome P. Claverie, Grégoire Leclair, Isabelle Marcotte, Souryvanh Nirasay, Antonella Badia   +4 more
openaire   +2 more sources

Lipid Nanoparticle‐Mediated CRISPR‐Cas13a Delivery for the Control of Bacterial Infection

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
New formulations of lipid nanoparticles (LNPs) that can deliver nucleic acids to Gram‐negative bacteria are proposed to combat bacterial infection. The delivery of nucleic acids by LNPs is aided by LNP‐helpers which weaken the bacterial outer membrane. LNPs encapsulating the Cas13a/gRNA expression vector achieve an antibacterial effect in both in vivo ...
Bookun Kim, Hwi Won Seo, Kyuri Lee, Dongeun Yong, Yoon Kyung Park, Yujin Lee, Solip Lee, Do‐Wan Kim, Dajeong Kim, Choong‐Min Ryu   +9 more
wiley   +1 more source

Viscous regularization and r-adaptive remeshing for finite element analysis of lipid membrane mechanics

, 2007
As two-dimensional fluid shells, lipid bilayer membranes resist bending and stretching but are unable to sustain shear stresses. This property gives membranes the ability to adopt dramatic shape changes. In this paper, a finite element model is developed
Alberts, Ayton, Bacia, Balluffi, Baumgart, Baumgart, Bozic, Božič, Byrd, Canham, Capovilla, Cirak, Cirak, Derényi, Do Carmo, Du, Du, Evans, Evans, Feng, Frey, Fygenson, Gompper, Heinrich, Heinrich, Helfrich, Ho, Hsu, Jaric, Jenkins, Jenkins, Jiang, Jülicher, Jülicher, Kawakatsu, Kraus, Lin Ma, Lipowsky, Nocedal, Noguchi, Noguchi, Powers, Seifert, Seifert, Seifert, Smith, Snapp, Sokolnikoff, Steigmann, Svetina, Svetina, Svetina, Taniguchi, Taniguchi, Toledano, Wang, Wiese, William S. Klug, Wintz, Zhu   +59 more
core   +2 more sources

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Arrangement of Annexin A2 tetramer and its impact on the structure and diffusivity of supported lipid bilayers

, 2010
Annexins are a family of proteins that bind to anionic phospholipid membranes in a Ca2+-dependent manner. Annexin A2 forms heterotetramers (Anx A2t) with the S100A10 (p11) protein dimer.
Barbara Windschiegl, Bert Nickel, Biener, Burger, Casal, Chasserot-Golaz, Claudia Steinem, Cremer, Daniel, Dermine, Dertinger, Dietrich, Esteban-Martín, Faure, Feigenson, Fenz, Filipenko, Fischer, Fritz, Georg Fritz, Gerke, Gilmanshin, Heimburg, Hochrein, Horton, Kirstin Fritz, Klauda, Kucerka, Kucerka, Ladha, Lambert, Lambert, Lewit-Bentley, Liangfang, Lin, Mattai, May, Menke, Miller, Nakata, Nevot, Nickel, Novakova, Parratt, Ratto, Reich, Reich, Richter, Richter, Rosengarth, Ross, Réty, Santos, Schalke, Schulz, Scomparin, Shreve, Trauble, Vacklin, Waisman, Wallace, Watkins   +61 more
core   +1 more source

Systematic Comparison of Commercial Uranyl‐Alternative Stains for Negative‐ and Positive‐Staining Transmission Electron Microscopy of Organic Specimens

Advanced Healthcare Materials, EarlyView.
Negative‐ and positive‐staining TEM is essential for rapid nanometer‐resolution characterization of organic specimens ranging from nanoparticles to cells. Uranyl salts are widely used negative‐/positive‐stains but are radioactive and highly toxic to users and the environment.
Vera M. Kissling, Stephanie Eitner, Davide Bottone, Gea Cereghetti, Peter Wick   +4 more
wiley   +1 more source

Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal‐Phenolic Networks

Advanced Healthcare Materials, EarlyView.
Small extracellular vesicles (sEVs) are encapsulated into protective shells composed of metal‐phenolic networks (MPNs) and secondary poly(ethylene glycol) layers. This surface modification approach enhances the storage stability of sEVs while maintaining their integrity and functionality. The shells can be selectively disassembled under mild conditions.
Chenyu Wang, Ailifeire Fulati, Kenta Kimura, Xianglan Li, Joseph J. Richardson, Mitsuru Naito, Kanjiro Miyata, Takanori Ichiki, Hirotaka Ejima   +8 more
wiley   +1 more source