Results 101 to 110 of about 74,745 (203)

Engineering Phosphatidylserine Containing Asymmetric Giant Unilamellar Vesicles

Membranes
The plasma membrane lipid distribution is asymmetric, with several anionic lipid species located in its inner leaflet. Among these, phosphatidylserine (PS) plays a crucial role in various important physiological functions.
Jake McDonough, Trevor A. Paratore, Hannah M. Ketelhohn, Bella C. DeCilio, Alonzo H. Ross, Arne Gericke   +5 more
doaj   +1 more source

Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase

eLife, 2019
The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients.
Maria E Falzone, Jan Rheinberger, Byoung-Cheol Lee, Thasin Peyear, Linda Sasset, Ashleigh M Raczkowski, Edward T Eng, Annarita Di Lorenzo, Olaf S Andersen, Crina M Nimigean, Alessio Accardi   +10 more
doaj   +1 more source

Formation of Supported Lipid Bilayers by Vesicle Fusion: Effect of Deposition Temperature

Langmuir, 2014
We have investigated the effect of deposition temperature on supported lipid bilayer formation via vesicle fusion. By using several complementary surface-sensitive techniques, we demonstrate that despite contradicting literature on the subject, high-quality bilayers can be formed below the main phase-transition temperature of the lipid.
Lind, Tania Kjellerup, Cardenas Gomez, Marite, Wacklin, Hanna   +2 more
openaire   +4 more sources

Modeling membrane nanotube morphology: the role of heterogeneity in composition and material properties. [PDF]

, 2020
Membrane nanotubes are dynamic structures that may connect cells over long distances. Nanotubes are typically thin cylindrical tubes, but they may occasionally have a beaded architecture along the tube.
Alimohamadi, Haleh, Ovryn, Ben, Rangamani, Padmini   +2 more
core  

Fast Membranes Hemifusion via Dewetting between Lipid Bilayers

, 2014
The behavior of lipid bilayer is important to understand the functionality of cells like the trafficking of ions between cells. Standard procedures to explore the properties of lipid bilayer and hemifused states typically use either supported membranes ...
Fleury, Jean-Baptiste, Seemann, Ralf, Vargas, Jose Nabor   +2 more
core   +1 more source

Novel broad spectrum virucidal molecules against enveloped viruses.

PLoS ONE, 2018
Viral infections are an important cause of death worldwide. Unfortunately, there is still a lack of antiviral drugs or vaccines for a large number of viruses, and this represents a remarkable challenge particularly for emerging and re-emerging viruses ...
Valeria Cagno, Cristina Tintori, Andrea Civra, Roberta Cavalli, Marika Tiberi, Lorenzo Botta, Annalaura Brai, Giulio Poli, Caroline Tapparel, David Lembo, Maurizio Botta   +10 more
doaj   +1 more source

Pores in Bilayer Membranes of Amphiphilic Molecules: Coarse-Grained Molecular Dynamics Simulations Compared with Simple Mesoscopic Models

, 2004
We investigate pores in fluid membranes by molecular dynamics simulations of an amphiphile-solvent mixture, using a molecular coarse-grained model. The amphiphilic membranes self-assemble into a lamellar stack of amphiphilic bilayers separated by solvent
Bouligand Y., Brodatzki U., C. Loison, Constantin D., F. Schmid, Hed G., Holmes M., Khanta M., Lawaczeck R., Lister J. D., Loison C., M. Mareschal, May S., Mecke K. R., Milchielsen K., Safran S. A., Sung W., Zahn D.   +17 more
core   +1 more source

Physico-chemical requirements and kinetics of membrane fusion of flavivirus-like particles. [PDF]

, 2015
Flaviviruses deliver their RNA genome into the host-cell cytoplasm by fusing their lipid envelope with a cellular membrane. Expression of the flavivirus pre-membrane and envelope glycoprotein genes in the absence of other viral genes results in the ...

core   +1 more source

Asymmetric membranes resulting from the fusion of two black lipid bilayers

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1974
Abstract When two black lipid bilayers are brought into close contact in the presence of divalent ions they interact, a process termed “fusion”. The resulting structure is suggested to be another bilayer with a multitude of intercalated solvent lenses and micelles.
openaire   +3 more sources

Effect of the S2’ site cleavage on SARS-CoV-2 spike

Nature Communications
SARS-CoV-2 initiates infection of host cells by fusing its envelope lipid bilayer with the cell membrane. To overcome kinetic barriers for membrane fusion, the virus-encoded spike (S) protein refolds from a metastable prefusion state to a lower energy ...
Wei Shi, GM Jonaid, Md Golam Kibria, Jacob Allen, Hanqin Peng, Sophia Rits-Volloch, Haisun Zhu, Shaowei Wang, Richard M. Walsh, Jianming Lu, Bing Chen   +10 more
doaj   +1 more source