Results 111 to 120 of about 744,052 (289)

Molecular dynamics computer simulations of lipid bilayers containing cholesterol [PDF]

, 2009
This thesis presents my research on molecular dynamics (MD) simulations of lipid bilayers. Some of the simulations were done on lipid bilayers containing one lipid component, while others were on lipid bilayers containing cholesterol and different ...
Zhang, Zhancheng
core   +1 more source

Measuring Blood Plasma Glutamine Levels Using a Nanopore‐Based Sensor

Advanced Healthcare Materials, EarlyView.
Glutamine (GLN) is a biomarker useful for predicting toxic ammonia accumulation. Here, we used a biosensor based on the Cytolysin A (ClyA) nanopore coupled with the GLN‐specific protein substrate‐binding domain 2 (SBD2) to demonstrate real‐time measurement of GLN in blood plasma, highlighting the potential for future point‐of‐care applications ...
Sofia B. Relvas, Iris M. Kormelink, Sandra Michel‐Souzy, Florian L. R. Lucas, Nieck J. van der Heide, Hans R. Waterham, Ramon Versteeg, Judith Jans, Loes I. Segerink, Carsten Wloka   +9 more
wiley   +1 more source

A criterion to identify the equilibration time in lipid bilayer simulations [PDF]

Papers in Physics, 2012
With the aim of establishing a criterion for identifying when a lipid bilayer has reached steady state using the molecular dynamics simulation technique, lipid bilayers of different composition in their liquid crystalline phase were simulated in aqueous ...
Rodolfo D. Porasso, José J. López Cascales   +1 more
doaj  

Coherent collective dynamics in phospholipid membranes: where are we now?

Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, 2020
We review the main achievements accomplished in the study of the coherent collective dynamics of phospholipid membranes, i.e., the collective vibrational excitations active on the sub-picoseconds to picoseconds time scale and terahertz frequencies, over ...
Valeria Conti Nibali, Caterina Branca, Alessandro Paciaroni, Ulderico Wanderlingh, Giovanna D'Angelo   +4 more
doaj   +1 more source

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Structure determination of lipid bilayers

Biophysical Journal, 1978
A method of determining the phases of X-ray reflections from oriented model membrane systems at low resolution is described. The method involves deconvolution and requires that d less than or equal to 2v where v is the width of the head group region within the bilayer and d is the thickness of the bilayer.
Worthington, C.R., Kharf, R.S.
openaire   +2 more sources

A Critical Call for Mechanistic Investigations of Metal‐Bacteria Interactions

Advanced Materials, EarlyView.
It is well established that the antibacterial properties of metals have tremendous importance for bioengineering applications. What is not as appreciated, however, is the reproducibility crisis in this field's vast literature. In this perspective, we highlight this reproducibility problem, discuss its sources, and suggest solutions towards focused ...
J. Rackwitz, A. Bandyopadhyay, S. Belkin, S. Bose, N. Eliaz, J. L. Gilbert, T. C. Lowe, F. Mücklich, R. J. Turner, C. C. Tasan   +9 more
wiley   +1 more source

DPD simulation to reproduce lipid membrane microdomains based on fragment molecular orbital calculations

Applied Physics Express
Lipid domains play a critical role in signal transduction and transport across cell membranes. The formation of domains in “HLC” ternary lipid bilayers composed of high transition temperature (high- Tm ) lipids, low- Tm lipids, and cholesterol (Chol) has
Hideo Doi, Yushi Osada, Yusuke Tachino, Koji Okuwaki, Melvin Wei Shern Goh, Ryugo Tero, Yuji Mochizuki   +6 more
doaj   +1 more source

A Molecular Dynamics Study of the Structural and Dynamical Properties of Putative Arsenic Substituted Lipid Bilayers

, 2013
Cell membranes are composed mainly of phospholipids which are in turn, composed of five major chemical elements: carbon, hydrogen, nitrogen, oxygen, and phosphorus.
Ratna Juwita, Jian-Ming Huang, Hui-Hsu Tsai, Jian-Bin Lee   +3 more
core   +1 more source