Results 151 to 160 of about 744,052 (289)
Advanced Science, EarlyView.Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang +11 more
wiley +1 more source
Advanced Science, EarlyView.A novel geometry‐resolved membrane platform provides a seamlessly integrated pipeline for studying curvature‐sensing proteins. By linking shotgun proteomics with quantitative imaging, this approach enables both the unbiased discovery and rigorous validation of novel sensors across the entire curvature range—positive, negative, and zero.
Takumi Komikawa +6 more
wiley +1 more source
Mesoporous supported lipid bilayers
, 2011 Lipid bilayers are commonly used as simplified model systems of living cell membranes. They have shown to be important components in the development of biosensing devices where the bilayer acts as a host for transmembrane proteins, such as ion channels ...
Claesson, Maria
core +1 more source
Advanced Science, EarlyView.The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu +4 more
wiley +1 more source
Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading
Advanced Science, EarlyView.Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong +5 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 2002 Reconstitution of membrane proteins into lipid bilayers is a powerful tool to analyze functional as well as structural areas of membrane protein research.
Rigaud J.-L.
doaj
An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Advanced Science, EarlyView.Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system
, 2007 The use of spark assisted chemical engraving (SACE) to produce glass apertures that are suitable for the formation of artificial bilayer lipid membranes is described.
Abu-Hantash, M. +3 more
core
Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications
Advanced Science, EarlyView.Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen +11 more
wiley +1 more source
POPC/Cholesterol lipid bilayers: A matter of polarity
, 2019 Water is an important component of lipid membranes and contributes for the stabilization of the bilayer structure. It determines the polarity gradient in lipid bilayers, since the amount of water at the lipid/water interface is higher than in the acyl
M. Martins, Jorge, Cristo, Joana
core +1 more source