Results 51 to 60 of about 1,227,492 (388)

Protocells: Modular Mesoporous Silica Nanoparticle-Supported Lipid Bilayers for Drug Delivery.

Small, 2016
Mesoporous silica nanoparticle-supported lipid bilayers, termed 'protocells,' represent a potentially transformative class of therapeutic and theranostic delivery vehicle.
Kimberly S. Butler, Paul N. Durfee, C. Théron, C. Ashley, Eric C. Carnes, C. J. Brinker   +5 more
semanticscholar   +1 more source

?2-Microglobulin Amyloid Fibril-Induced Membrane Disruption Is Enhanced by Endosomal Lipids and Acidic pH [PDF]

, 2014
Although the molecular mechanisms underlying the pathology of amyloidoses are not well understood, the interaction between amyloid proteins and cell membranes is thought to play a role in several amyloid diseases. Amyloid fibrils of ?2-microglobulin (?2m)
A Halle, A Ivankin, AD Petelska, AM Smith, B Boland, B Reed, C Cecchi, C Luquain, CJ Sarell, CL Bergstrom, CM Franzin, D Eisenberg, D Freeman, DE Lee, DP Smith, EE Ambroggio, Eric W. Hewitt, F Ferrone, F Gejyo, G van Meer, H Ohvo-Rekila, HD Gallala, HE White, I Benilova, IJ Morten, J Brotheru, J Brotherus, J Pan, J Villanueva, J Zimmerberg, JH Lee, JN Chebukati, JR Wherrett, JW Becker, K Berthelot, K Ditaranto, Kevin W. Tipping, L Milanesi, L Pieri, L Pieri, L Rajendran, M Arrasate, M Bostrom, M Bucciantini, M Duan, M Garcia-Garcia, M Stefani, MF Sciacca, MFM Engel, MFM Sciacca, MP Fogarty, MR Eftink, MY Porter, N Cremades, N Demaurex, N Liguori, Neil A. Ranson, NM Kad, NP Reynolds, Patrick van der Wel, Paul A. Beales, Rebecca Thompson, RF Chen, S Huterer, S Valleix, S Yamamoto, Sheena E. Radford, SL Myers, Sophia C. Goodchild, T Eichner, T Hayakawa, T Kobayashi, T Kobayashi, T Kobayashi, T Kobayashi, T Ookoshi, T Sheynis, T Umeda, Tania Sheynis, TE Frederick, TE Frederick, TL Williams, TL Williams, TP Knowles, TPJ Knowles, TR Jahn, TR Jahn, V Soura, VJ McParland, VN Uversky, Wei-Feng Xue, WF Xue, WF Xue, WF Xue, WF Xue, WF Xue, WG Wood, Y Hirakura, ZS Ji   +98 more
core   +4 more sources

Amyloid-β oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy

Journal of Biological Chemistry, 2019
The ability of amyloid-β peptide (Aβ) to disrupt membrane integrity and cellular homeostasis is believed to be central to Alzheimer's disease pathology. Aβ is reported to have various impacts on the lipid bilayer, but a clearer picture of Aβ influence on
David C. Bode, M. Freeley, Jon Nield, M. Palma, J. H. Viles   +4 more
semanticscholar   +1 more source

Microcavity supported lipid membranes: versatile platforms for building asymmetric lipid bilayers and for protein recognition [PDF]

, 2019
Microcavity supported lipid bilayers (MSLB) are contact-free membranes suspended across aqueousfilled pores that maintain the lipid bilayer in a highly fluidic state and free from frictional interactions with substrate.
Berselli, Guilherme, Keyes, Tia E., Murphy, Paul V., Ramadurai, Sivaramakrishnan, Sarangi, Nirod Kumar   +4 more
core   +1 more source

Lipid/water interface of galactolipid bilayers in different lyotropic liquid-crystalline phases

Frontiers in Molecular Biosciences, 2022
In this study, carried out using computational methods, the organisation of the lipid/water interface of bilayers composed of galactolipids with both α-linolenoyl acyl chains is analysed and compared in three different lyotropic liquid-crystalline phases.
Jakub Hryc, Robert Szczelina, Michal Markiewicz, Marta Pasenkiewicz-Gierula   +3 more
doaj   +1 more source

Lateral transport of domains in anionic lipid bilayer membranes under DC electric fields: A coarse-grained molecular dynamics study [PDF]

, 2023
Dynamic lateral transport of lipids, proteins, and self-assembled structures in biomembranes plays crucial roles in diverse cellular processes. In this study, we perform a coarse-grained molecular dynamics simulation on a vesicle composed of a binary mixture of neutral and anionic lipids to investigate the lateral transport of individual lipid ...
arxiv   +1 more source

Mapping surface charge density of lipid bilayers by quantitative surface conductivity microscopy

Nature Communications, 2016
Local surface charge density of lipid membranes influences membrane–protein interactions leading to distinct functions in all living cells, and it is a vital parameter in understanding membrane-binding mechanisms, liposome design and drug delivery ...
L. Klausen, Thomas Fuhs, M. Dong
semanticscholar   +1 more source

Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes [PDF]

, 2018
Huntington disease (HD) is an inherited neurodegenerative disease caused by the expansion beyond a critical threshold of a polyglutamine (polyQ) tract near the N-terminus of the huntingtin (htt) protein. Expanded polyQ promotes the formation of a variety
Campbell, Warren A., Chaibva, Maxmore, Frey, Shelli L., Gao, Xiang, Jain, Pranav, Legleiter, Justin   +5 more
core   +4 more sources

Lipids modulate the increase of BK channel calcium sensitivity by the β1 subunit. [PDF]

PLoS ONE, 2014
Co-expression of the auxiliary β1 subunit with the pore forming α subunit of BK dramatically alters apparent calcium sensitivity. Investigation of the mechanism underlying the increase in calcium sensitivity of BK in smooth muscle has concentrated on the
Chunbo Yuan, Cristina Velázquez-Marrero, Alexandra Bernardo, Steven N Treistman   +3 more
doaj   +1 more source

Hydrophobic silver nanoparticles trapped in lipid bilayers: Size distribution, bilayer phase behavior, and optical properties

Journal of Nanobiotechnology, 2008
Background Lipid-based dispersion of nanoparticles provides a biologically inspired route to designing therapeutic agents and a means of reducing nanoparticle toxicity.
Bothun Geoffrey D
doaj   +1 more source