Results 71 to 80 of about 744,052 (289)

Actin Assembly at Model-Supported Lipid Bilayers [PDF]

, 2013
We report on the use of supported lipid bilayers to reveal dynamics of actin polymerization from a nonpolymerizing subphase via cationic phospholipids. Using varying fractions of charged lipid, lipid mobility, and buffer conditions, we show that dynamics
Johnson, BRG, Olmsted, PD, Heath, GR, Connell, SD, Evans, SD   +4 more
core   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Lipid Corona Formation from Nanoparticle Interactions with Bilayers and Membrane-Specific Biological Outcomes [PDF]

, 2017
While mixing nanoparticles with certain biological molecules can result in coronas that afford some control over how engineered nanomaterials interact with living systems, corona formation mechanisms remain enigmatic.
Dehong, Hu, Catherine J., Murphy, Gene, Chong, Angela, Schmoldt, Joel A., Pedersen, Qiang, Cui, Thomas R, Kuech, Arielle C, Mensch, Xi, Zhang, Laura L., Olenick, Ariane, Vartanian, Franz, Geiger, Katherine R., Hurley, Augusto, Millevolte, Alicia C., McGeachy, Aurash, Mohaimani, Eric S., Melby, Stephanie R., Walter, Rebecca, Klaper, Julianne M., Troiano, Jared, Bozich, Christy L., Haynes, Jiewei, Hong, Marco D., Torelli, Merve, Dogangun, Leili, Zhang, Tianzhe, Li, Samuel, Lohse, Rigoberto, Hernandez, Ian, Gunsolus, Z. Vivian, Feng, Robert J., Hamers, Tian, Qiu, Joe, Dalluge, Galya, Orr   +34 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Energy transfer in lipid bilayers

Biophysical Journal, 1979
The quenching of fluorescence due to energy transfer between a dilute, random array of donor and acceptor chromophores in lipid bilayer was measured and compared to theoretical expressions developed to predict the decrease in emission intensity under these circumstances. The observed intensity was found to be the same function of quencher concentration
Estep, T.N., Thompson, T.E.
openaire   +2 more sources

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Computational Investigation of the Effect of Lipid Membranes on Ion Permeation in Gramicidin A

Membranes, 2016
Membrane proteins are embedded in a lipid bilayer and interact with the lipid molecules in subtle ways. This can be studied experimentally by examining the effect of different lipid bilayers on the function of membrane proteins.
Jeffry Setiadi, Serdar Kuyucak
doaj   +1 more source

Dielectric Properties of Phosphatidylcholine Membranes and the Effect of Sugars

Membranes, 2021
Simple carbohydrates are associated with the enhanced risk of cardiovascular disease and adverse changes in lipoproteins in the organism. Conversely, sugars are known to exert a stabilizing effect on biological membranes, and this effect is widely ...
Victoria Vitkova, Vesela Yordanova, Galya Staneva, Ognyan Petkov, Angelina Stoyanova-Ivanova, Krassimira Antonova, Georgi Popkirov   +6 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Antibiotic Loaded Phytosomes as a Way to Develop Innovative Lipid Formulations of Polyene Macrolides

Pharmaceutics
Background: The threat of antibiotic resistance of fungal pathogens and the high toxicity of the most effective drugs, polyene macrolides, force us to look for new ways to develop innovative antifungal formulations.
Svetlana S. Efimova, Olga S. Ostroumova
doaj   +1 more source