Results 61 to 70 of about 1,686 (274)

Is there Progress? An Overview of Select Biomarker Candidates for Major Depressive Disorder [PDF]

, 2016
Major Depressive Disorder (MDD) contributes to a significant worldwide disease burden, expected to be second only to heart disease by 2050. However, accurate diagnosis has been a historical weakness in clinical psychiatry.
Aebersold, Aihara, Allard, Alvarez, Ancelin, Anttila, Au, Aydemir, Barbosa, Belmaker, Belzeaux, Berlin, Bilello, Bilici, Birkenhäger, Blum, Bocchio-Chiavetto, Boksa, Boldrini, Bremmer, Brouwer, Brummett, Brundin, Brydon, Bus, Cai, Capuron, Carta, Chueire, Chung, Cirulli, Covington, Covington, Covington, Cuthbert, Cuthbert, Dantzer, de Azevedo Cardoso, Dell’Osso, Demet, Demet, Ding, Diniz, Diniz, Ditzen, Doyle, Eisenberger, Enaw, Engum, Eren, Fam, Ferrari, Fjaellegaard, Forlenza, Frodl, Fuchikami, Gadow, Gatt, Gold, Goldstein, Gotlib, Gottesman, Haggerty, Haggerty, Hannestad, Hashimoto, Hasler, Hayley, He, Heim, Hellweg, Heuser, Hoen, Holsboer, Holtmann, Hwang, Im, Irie, Januar, Jevtović, Joshi, Kalia, Kang, Karlović, Kessler, Kessler, Khanzode, Kinoshita, Kirkegaard, Kodydková, Korgaonkar, Krishnan, Kuijpens, Kunugi, Kunugi, Kurita, Lakhan, Lamers, Lanquillon, Lapidus, Lavebratt, Lee, Lee, Lee, Lekman, Lener, Leonard, Lichtblau, Licinio, Lindon, Lindqvist, Lindqvist, Liu, Long, Lopresti, Lu, Luca, López-León, Maccarrone, Maes, Maes, Maes, Mamdani, Mannie, Martino, Martins-de-Souza, Martins-de-Souza, Masi, Maussion, Menke, Michel, Mikova, Miller, Miller, Miller, Miller, Mitchell, Molendijk, Moretti, Motivala, Munno, Munzer, Myint, Müller, Müssig, Nelemans, Nemeroff, Nestler, Ng, Ninan, Numata, Oral, Owen, Owens, Pal, Papakostas, Pariante, Park, Paslakis, Podlipný, Pomara, Premachandra, Raison, Raison, Raison, Ribeiro, Ripke, Rodrigues, Rothermundt, Rudolf, Salomon, Sapolsky, Sarandol, Satomura, Saus, Schulze, Sen, Shea, Shi, Shibuya, Shimizu, Slopen, Smaga, Smart, Song, Sprangers, Stelzhammer, Stetler, Sullivan, Sundermann, Szebeni, Szuster-Ciesielska, Talarowska, Teyssier, Thiagarajah, Tsankova, Tsankova, Tuglu, Uddin, Uddin, Uher, Uher, Valkanova, van de Ven, Varghese, Vetter, Villanueva, Viscogliosi, Vreeburg, Wang, Waters, Weaver, Wei, Williams, Wolfers, Wolkowitz, Woods, World Health Organization, Yasui-Furukori, Young, Zeugmann, Zhang, Zheng, Zhou, Zobel   +224 more
core   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Target organ remodeling features in patients with essential hypertension in combination with diabetes and obesity [PDF]

, 2015
У статті представлені результати порівняльного аналізу параметрів структурно функціонального ремоделювання серця, судин і печінки у хворих на гіпертонічну хворобу в поєднанні з цукровим діабетом 2 типу та ожирінням. Встановлено, що незалежно від величини
Kochueva, N.M., Kyrychenko, Nataliia Mykolaivna, Psarova, Valentyna Hryhorivna, Shalimova, A.S., Кириченко, Наталия Николаевна, Кириченко, Наталія Миколаївна, Кочуева, Н.М., Кочуєва, Н.М., Псарева, Валентина Григорьевна, Псарьова, Валентина Григорівна, Шалимова, А.С., Шалімова, А.С.   +11 more
core  

Dopamine elevates and lowers astroglial Ca(2+) through distinct pathways depending on local synaptic circuitry [PDF]

, 2016
Whilst astrocytes in culture invariably respond to dopamine with cytosolic Ca(2+) rises, the dopamine sensitivity of astroglia in situ and its physiological roles remain unknown. To minimize effects of experimental manipulations on astroglial physiology,
Bard, L, Henneberger, C, Jennings, A, Rusakov, DA, Semyanov, A, Tyurikova, O, Zheng, K   +6 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Lipid Changes in the Eye Concomitant with the Development of Atherosclerosis in the Aorta in the Rabbit [PDF]

Circulation Research, 1968
The lipid changes that occur in the eyes and aortas of male Dutch belted rabbits maintained on 1% dietary cholesterol for 1 to 3 months were studied. In the cornea, iris, ciliary body, and aorta, the most noteworthy lipid change was in tissue cholesterol, which increased with increased time of feeding cholesterol.
H G, Roscoe, A W, Vogel
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

云南不同地区无患子籽油脂肪酸组成 及脂质伴生物变异分析Analysis of variations in fatty acid composition and lipid concomitants of Sapindus mukorossi Gaertn. seed oil from different regions of Yunnan

Zhongguo youzhi
旨在为无患子籽油的综合开发利用及培育无患子优良品种提供参考，以云南16 个地区的无患子种仁为原料提取油脂，对无患子种仁含油率、油脂的脂肪酸组成和脂质伴生物含量等相关的17个指标进行测定，结合相关性分析、聚类分析和主成分分析对不同地区无患子种质品质进行比较和综合评价。结果表明：16个地区无患子的17个指标间差异较大，变异系数在5%~133%，其中棕榈烯酸（133%）和α-生育酚（66%）变异较大，油酸（5%）和种仁含油率（8%）变异较小；17个指标中种仁含油率、油酸、硬脂酸、花生酸、二十二碳酸、α-生育酚、
毛一帆，杨妮，赵红珍，王怡匀，高永青，王连春MAO Yifan, YANG Ni, ZHAO Hongzhen, WANG Yiyun, GAO Yongqing, WANG Lianchun
doaj   +1 more source

Metabolic changes in concussed American football players during the acute and chronic post-injury phases [PDF]

, 2011
Background Despite negative neuroimaging findings many athletes display neurophysiological alterations and post-concussion symptoms that may be attributable to neurometabolic alterations.
Luke C Henry, Sébastien Tremblay, Suzanne Leclerc, Abdesselam Khiat, Yvan Boulanger, Dave Ellemberg, Maryse Lassonde   +6 more
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source